T
Tom Deboer
Researcher at Leiden University Medical Center
Publications - 98
Citations - 6362
Tom Deboer is an academic researcher from Leiden University Medical Center. The author has contributed to research in topics: Sleep deprivation & Circadian rhythm. The author has an hindex of 37, co-authored 90 publications receiving 5480 citations. Previous affiliations of Tom Deboer include Loyola University Medical Center & Leiden University.
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The two-process model of sleep regulation: a reappraisal
TL;DR: Sleep appears to have not only a short‐term, use‐dependent function; it also serves to enforce rest and fasting, thereby supporting the optimization of metabolic processes at the appropriate phase of the 24‐h cycle.
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Altered circadian activity rhythms and sleep in mice devoid of prion protein.
Irene Tobler,S. E. Gaus,Tom Deboer,Peter Achermann,Markus Fischer,Thomas Rülicke,Markus Moser,Bruno Oesch,P A McBride,Jean Manson +9 more
TL;DR: The results indicate that the pathology of at least one of the inherited prion diseases, fatal familial insomnia, where there is a profound alteration in sleep and the daily rhythms of many hormones, may be related to the normal function of the prion protein.
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Sleep states alter activity of suprachiasmatic nucleus neurons.
TL;DR: The results indicate that the 24-hour pattern in electrical activity that is controlled by the molecular machinery of the SCN is substantially modified by afferent information from the central nervous system.
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Sleep and sleep regulation in normal and prion protein-deficient mice.
TL;DR: It is suggested that PrP plays a role in promoting sleep continuity by comparing baseline recordings and the effects of sleep deprivation in PrP knockout mice and wild-type controls, which are the mice used for most gene targeting experiments and whose behavior is not well characterized.
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Effects of sleep deprivation on sleep and sleep EEG in three mouse strains: empirical data and simulations
TL;DR: The capacity of the model to predict SWA in nonREM sleep on the basis of the temporal organization of sleep in mice was tested and provided a basis for the use of gene targeted mice to investigate the underlying mechanisms.