Tom G. de Leeuw

TL;DR: In this article, a single-center, randomized, double-blind study was conducted in a level 3 pediatric intensive care unit in Rotterdam, the Netherlands, to determine whether intravenous paracetamol (acetaminophen) would significantly reduce morphine requirements in neonates and infants after major surgery.

TL;DR: In this paper, a single-center, randomized, double-blind study was conducted in a level 3 pediatric intensive care unit in Rotterdam, the Netherlands, to determine whether intravenous paracetamol (acetaminophen) would significantly reduce morphine requirements in neonates and infants after major surgery.

TL;DR: The discriminative properties of the BIS monitor for the state of consciousness were comparable between the 2 groups according to the receiver operating characteristic curves, Nevertheless, the optimal cutoff BIS value for discrimination between conscious and unconscious state was 28 points lower for the intellectually disabled group.

TL;DR: Among infants undergoing major surgery, postoperative use of intermittent intravenous paracetamol compared with continuous morphine resulted in a lower cumulative morphine dose over 48 hours, and pain scores and adverse effects were not significantly different between groups.

TL;DR: Music interventions do not seem to benefit all young infants undergoing surgery, and the potential benefits of music interventions in the preoperative period and in more distressed children warrant further exploration.