T
Tomasz Mroczek
Researcher at Medical University of Lublin
Publications - 57
Citations - 855
Tomasz Mroczek is an academic researcher from Medical University of Lublin. The author has contributed to research in topics: High-performance liquid chromatography & Mass spectrometry. The author has an hindex of 16, co-authored 50 publications receiving 661 citations.
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Simultaneous determination of N-oxides and free bases of pyrrolizidine alkaloids by cation-exchange solid-phase extraction and ion-pair high-performance liquid chromatography
TL;DR: The applied HPIPC gradient procedure was suitable for separation of PAs with various types of structures (N-oxides, free bases, otonecine-PAs) and was used in searching for PAs in plant derived samples from Symphytum sp.
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Solid-liquid extraction and cation-exchange solid-phase extraction using a mixed-mode polymeric sorbent of Datura and related alkaloids.
TL;DR: Tropane alkaloids solid-liquid extraction methods were developed and comprised ambient pressure ones: extraction with hot solvent, extraction at room temperature, on ultrasonic bath as well as pressurised liquid extraction (PLE) techniques.
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Highly efficient, selective and sensitive molecular screening of acetylcholinesterase inhibitors of natural origin by solid-phase extraction-liquid chromatography/electrospray ionisation-octopole-orthogonal acceleration time-of-flight-mass spectrometry and novel thin-layer chromatography-based bioautography.
TL;DR: More potent than galanthamine AChE inhibitor namely 1,2-dihydrogalanthamine in Narcissus jonquilla 'Pipit' extract could be found (with IC(50) value 0.19 microM lower of about 42% than that of galanthamines).
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Pressurized liquid extraction and anticholinesterase activity-based thin-layer chromatography with bioautography of Amaryllidaceae alkaloids.
Tomasz Mroczek,Jacek Mazurek +1 more
TL;DR: Optimal extraction technique-pressurized liquid extraction was optimised for extraction of lycorine and galanthamine from Narcissus jonquilla 'Pipit' and was much more effective than previously applied hot-solvent extraction, microwave-assisted extraction (MAE) or ultrasound- assisted extraction (USAE).
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Application of hydrostatic CCC–TLC–HPLC–ESI-TOF-MS for the bioguided fractionation of anticholinesterase alkaloids from Argemone mexicana L. roots
TL;DR: The first time galanthamine has been reported in the extract of Mexican prickly poppy and the first time it has been identified in any member of the Papaveraceae family, in the significant quantity of 0.77 %.