T
Tomotake Shirono
Researcher at Kurume University
Publications - 51
Citations - 655
Tomotake Shirono is an academic researcher from Kurume University. The author has contributed to research in topics: Hepatocellular carcinoma & Medicine. The author has an hindex of 10, co-authored 36 publications receiving 297 citations.
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Journal ArticleDOI
Clinical Significance of Adverse Events for Patients with Unresectable Hepatocellular Carcinoma Treated with Lenvatinib: A Multicenter Retrospective Study.
Shigeo Shimose,Hideki Iwamoto,Takashi Niizeki,Tomotake Shirono,Yu Noda,Naoki Kamachi,Shusuke Okamura,Masahito Nakano,Hideya Suga,Ryoko Kuromatsu,Taizo Yamaguchi,Takumi Kawaguchi,Masatoshi Tanaka,Kazunori Noguchi,Hironori Koga,Takuji Torimura +15 more
TL;DR: It is concluded that the appearance of hypertension has potential as an early surrogate marker to predict improved prognosis and careful management to avoid discontinuation of treatment leads to longer survival in patients receiving LEN.
Journal ArticleDOI
Sorafenib for the treatment of advanced hepatocellular carcinoma with extrahepatic metastasis: a prospective multicenter cohort study
Masahito Nakano,Masatoshi Tanaka,Ryoko Kuromatsu,Hiroaki Nagamatsu,Nobuyoshi Tajiri,Manabu Satani,Takashi Niizeki,Hajime Aino,Shusuke Okamura,Hideki Iwamoto,Shigeo Shimose,Tomotake Shirono,Hironori Koga,Takuji Torimura +13 more
TL;DR: The results indicated that sorafenib could be administered for hepatic reserve and as long‐term treatment for advanced HCC patients regardless of their extrahepatic metastasis status.
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Effects of in‐hospital exercise on liver function, physical ability, and muscle mass during treatment of hepatoma in patients with chronic liver disease
Shunji Koya,Takumi Kawaguchi,Ryuki Hashida,Emiko Goto,Hiroo Matsuse,Hiromichi Saito,Keisuke Hirota,Ryoko Taira,Yoshiko Matsushita,Minami Imanaga,Ayu Nagamatsu,Tomotake Shirono,Shigeo Shimose,Hideki Iwamoto,Takashi Niizeki,Ryoko Kuromatsu,Hiroko Miura,Naoto Shiba,Takuji Torimura +18 more
TL;DR: The effects of therapeutic exercise on liver function, 6MWT, and skeletal muscle mass during HCC treatment in patients with CLD are investigated.
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Prognostic impact of transcatheter arterial chemoembolization (TACE) combined with radiofrequency ablation in patients with unresectable hepatocellular carcinoma: Comparison with TACE alone using decision-tree analysis after propensity score matching.
Shigeo Shimose,Masatoshi Tanaka,Hideki Iwamoto,Takashi Niizeki,Tomotake Shirono,Hajime Aino,Yu Noda,Naoki Kamachi,Shusuke Okamura,Masahito Nakano,Ryoko Kuromatsu,Takumi Kawaguchi,Atsushi Kawaguchi,Hironori Koga,Yoshinori Yokokura,Takuji Torimura +15 more
TL;DR: The impact of TACE combined with radiofrequency ablation (TACE+RFA) on the prognosis of HCC patients using decision‐tree analysis after propensity score matching is evaluated.
Journal ArticleDOI
Weekends-Off Lenvatinib for Unresectable Hepatocellular Carcinoma Improves Therapeutic Response and Tolerability toward Adverse Events.
Hideki Iwamoto,Hiroyuki Suzuki,Shigeo Shimose,Takashi Niizeki,Masahito Nakano,Tomotake Shirono,Shusuke Okamura,Yu Noda,Naoki Kamachi,Toru Nakamura,Atsutaka Masuda,Takahiko Sakaue,Toshimitsu Tanaka,Dan Nakano,Miwa Sakai,Taizo Yamaguchi,Ryoko Kuromatsu,Hironori Koga,Takuji Torimura +18 more
TL;DR: Weekends-off administration of lenvatinib was useful to recover the therapeutic response and tolerability toward AEs and the mouse hepatoma model showed that weekends- off administration contributed to recovery of vascularity in the organs.