T
Tomozumi Takatani
Researcher at Brigham and Women's Hospital
Publications - 7
Citations - 291
Tomozumi Takatani is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Insulin receptor & Unfolded protein response. The author has an hindex of 6, co-authored 7 publications receiving 256 citations. Previous affiliations of Tomozumi Takatani include Chiba University.
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Journal ArticleDOI
Correction: Corrigendum: IRS1 deficiency protects β-cells against ER stress-induced apoptosis by modulating sXBP-1 stability and protein translation
Tomozumi Takatani,Jun Shirakawa,Michael W. Roe,Colin A. Leech,Bernhard Maier,Raghavendra G. Mirmira,Rohit N. Kulkarni +6 more
TL;DR: Scientific Reports 6: Article number: 28177; published online: 05 July 2016; updated: 10 October 2016 .
Journal ArticleDOI
Insulin Signaling Regulates the FoxM1/PLK1/CENP-A Pathway to Promote Adaptive Pancreatic β Cell Proliferation.
Jun Shirakawa,Megan Fernandez,Tomozumi Takatani,Abdelfattah El Ouaamari,Prapaporn Jungtrakoon,Erin R. Okawa,Wei Zhang,Peng Yi,Alessandro Doria,Rohit N. Kulkarni +9 more
TL;DR: The data implicate the insulin-FoxM1/PLK1/CENP-A pathway-regulated mitotic cell-cycle progression as an essential component in the β cell adaptation to delay and/or prevent progression to diabetes.
Preserved DNA Damage Checkpoint Pathway Protects against Complications in Long-Standing Type 1 Diabetes
Shweta Bhatt,Manoj K. Gupta,Mogher Khamaisi,Rachael Martinez,Marina A. Gritsenko,Bridget K. Wagner,Volker Busskamp,Jun Shirakawa,Gongxiong Wu,Chong Wee Liew,Therese R. W. Clauss,Ivan Achel Valdez,Abdelfattah El Ouaamari,Ercument Dirice,Tomozumi Takatani,Hillary A. Keenan,Richard D. Smith,George M. Church,Amy J. Wagers,Wei-Jun Qian,George L. King,Rohit N. Kulkarni,Patrick Guye,Ron Weiss +23 more
TL;DR: It is proposed that knockdown of miR200 in Medalist +C fibroblasts and iPSCs rescued checkpoint protein expression and reduced DNA damage and is proposed as a potential therapeutic target for treating complications of diabetes.
Journal ArticleDOI
IRS1 deficiency protects β-cells against ER stress-induced apoptosis by modulating sXBP-1 stability and protein translation
Tomozumi Takatani,Jun Shirakawa,Michael W. Roe,Colin A. Leech,Bernhard Maier,Raghavendra G. Mirmira,Rohit N. Kulkarni +6 more
TL;DR: The observations suggest that IRS1 could be a therapeutic target for β-cell protection against ER stress-mediated cell death by modulating XBP-1 stability, protein synthesis, and Ca2+ storage in the ER.
IRS1 deficiency protects β-cells against ER stress-induced apoptosis by modulating sXBP-1 stability and protein translation
Tomozumi Takatani,Jun Shirakawa,Michael W. Roe,Colin A. Leech,Bernhard Maier,Raghavendra G. Mirmira,Rohit N. Kulkarni +6 more
TL;DR: In this paper, the authors showed that β-cells deficient in IRS1 (IRS1KO) are resistant to ER stress-mediated apoptosis, while IRS2 deficiency makes them susceptible to ER-induced apoptosis.