H
Hillary A. Keenan
Researcher at Joslin Diabetes Center
Publications - 45
Citations - 1325
Hillary A. Keenan is an academic researcher from Joslin Diabetes Center. The author has contributed to research in topics: Diabetes mellitus & Type 1 diabetes. The author has an hindex of 15, co-authored 42 publications receiving 1063 citations. Previous affiliations of Hillary A. Keenan include Mount Sinai Hospital, Toronto & Genzyme.
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Journal ArticleDOI
Residual Insulin Production and Pancreatic β-Cell Turnover After 50 Years of Diabetes: Joslin Medalist Study
Hillary A. Keenan,Jennifer K. Sun,Jared Levine,Alessandro Doria,Lloyd Paul Aiello,George S. Eisenbarth,Susan Bonner-Weir,George L. King +7 more
TL;DR: Demonstration of persistence and function of insulin-producing pancreatic cells suggests the possibility of a steady state of turnover in which stimuli to enhance endogenous β cells could be a viable therapeutic approach in a significant number of patients with type 1 diabetes, even for those with chronic duration.
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Clinical factors associated with resistance to microvascular complications in diabetic patients of extreme disease duration: the 50-year medalist study.
Hillary A. Keenan,Tina Costacou,Jennifer K. Sun,Alessandro Doria,Jerry Cavellerano,Joseph M. Coney,Trevor J. Orchard,Lloyd Paul Aiello,George L. King +8 more
TL;DR: The prevalence of complications and associated risk factors in a large number of individuals who have been insulin dependent for ≥50 years and who were awarded the Joslin Medal between 1997 and 2003 are characterized.
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The effect of vitamin E on endothelial function of micro- and macrocirculation and left ventricular function in type 1 and type 2 diabetic patients.
Panayiotis A. Economides,Lalita Khaodhiar,Antonella Caselli,A. Enrique Caballero,Hillary A. Keenan,Sven-Erik Bursell,George L. King,Michael T. Johnstone,Edward S. Horton,Aristidis Veves +9 more
TL;DR: It is concluded that long-term treatment with 1,800 IU of vitamin E has no beneficial effects on endothelial or left ventricular function in diabetic patients and the use of high dosage vitamin E cannot be recommended.
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PKCδ inhibition normalizes the wound-healing capacity of diabetic human fibroblasts
Mogher Khamaisi,Sayaka Katagiri,Hillary A. Keenan,Kyoungmin Park,Yasutaka Maeda,Qian Li,Weier Qi,Thomas Thomou,Danielle Eschuk,Ana Tellechea,Aris Veves,Chenyu Huang,Dennis P. Orgill,Amy J. Wagers,George L. King +14 more
TL;DR: Pharmacologic inhibition and siRNA-mediated knockdown of PKCδ or expression of a dominant-negative isoform restored insulin signaling of p-AKT and VEGF expression in vitro and improved wound healing in vivo and suggest PKC δ inhibition as a potential therapy to improve wounds healing in diabetic patients.
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Genotype‐phenotype relationships in mucopolysaccharidosis type I (MPS I): Insights from the International MPS I Registry
Lorne A. Clarke,Roberto Giugliani,Nathalie Guffon,Simon Jones,Hillary A. Keenan,Maria Veronica Munoz-Rojas,Torayuki Okuyama,David Viskochil,Chester B. Whitley,Frits A. Wijburg,Joseph Muenzer +10 more
TL;DR: A close genotype/phenotype correlation in MPS I is illustrated but the presence of unique IDUA missense variants remains a challenge for disease prediction.