Showing papers by "Toni K. Choueiri published in 2005"
01 Sep 2005
TL;DR: A patient with acute myeloid leukemia whose febrile neutropenia was treated with daptomycin and who later developed daptomecin-resistant Enterococcus faecium infection is described.
Abstract: Daptomycin is a lipopeptide antimicrobial used for the treatment of aerobic gram-positive skin and soft tissue infections. We describe a patient with acute myeloid leukemia whose febrile neutropenia was treated with daptomycin and who later developed daptomycin-resistant Enterococcus faecium infection. Defervescence and negative blood cultures ensued after treatment with linezolid. Guidelines for testing daptomycin susceptibilities of enterococci include breakpoints only for vancomycin-susceptible Enterococcus faecalis , making interpretation of minimum inhibitory concentrations for common clinical infections difficult. No enterococcal cross-resistance has been reported among daptomycin, linezolid, or quinupristin-dalfopristin, and these agents may be viable alternatives.
72 citations
TL;DR: DVd-R is an effective chemotherapeutic regimen in patients with RMM who progressed or did not respond to VAD like regimens or to Thalidomide containing regimens, produces a high response rate among chemotherapy resistant patients, and has a manageable toxicity profile.
18 citations
TL;DR: Overall, QT and QTc intervals returned to baseline with subsequent doses indicating the absence of a cumulative dose-effect, and ATO can be safely administered to patients with MM when electrolytes and concomitant medications are appropriately managed.
2 citations