T
Toni Lewis
Researcher at GlaxoSmithKline
Publications - 1
Citations - 205
Toni Lewis is an academic researcher from GlaxoSmithKline. The author has contributed to research in topics: Bromodomain. The author has an hindex of 1, co-authored 1 publications receiving 184 citations.
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Identification of a Novel Series of Bet Family Bromodomain Inhibitors: Binding Mode and Profile of I-Bet151 (Gsk1210151A).
Jonathan Thomas Seal,Yann Lamotte,Frédéric Donche,Anne Marie Jeanne Bouillot,Olivier Mirguet,Françoise Gellibert,Edwige Nicodeme,Gael Krysa,Jorge Kirilovsky,Soren Beinke,Scott McCleary,Inma Rioja,Paul Bamborough,Chun-wa Chung,Laurie J. Gordon,Toni Lewis,Ann Louise Walker,Leanne Cutler,Dave Lugo,David Matthew Wilson,Jason Witherington,Kevin Lee,Rab K. Prinjha +22 more
TL;DR: A novel series of quinoline isoxazole BET family bromodomain inhibitors shows good oral bioavailability in both the rat and minipig as well as demonstrating efficient suppression of bacterial induced inflammation and sepsis in a murine in vivo endotoxaemia model.