S
Scott McCleary
Researcher at GlaxoSmithKline
Publications - 8
Citations - 565
Scott McCleary is an academic researcher from GlaxoSmithKline. The author has contributed to research in topics: Syk & B-cell receptor. The author has an hindex of 7, co-authored 8 publications receiving 483 citations.
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Journal ArticleDOI
Identification of a Novel Series of Bet Family Bromodomain Inhibitors: Binding Mode and Profile of I-Bet151 (Gsk1210151A).
Jonathan Thomas Seal,Yann Lamotte,Frédéric Donche,Anne Marie Jeanne Bouillot,Olivier Mirguet,Françoise Gellibert,Edwige Nicodeme,Gael Krysa,Jorge Kirilovsky,Soren Beinke,Scott McCleary,Inma Rioja,Paul Bamborough,Chun-wa Chung,Laurie J. Gordon,Toni Lewis,Ann Louise Walker,Leanne Cutler,Dave Lugo,David Matthew Wilson,Jason Witherington,Kevin Lee,Rab K. Prinjha +22 more
TL;DR: A novel series of quinoline isoxazole BET family bromodomain inhibitors shows good oral bioavailability in both the rat and minipig as well as demonstrating efficient suppression of bacterial induced inflammation and sepsis in a murine in vivo endotoxaemia model.
Journal ArticleDOI
The BAFF Receptor Transduces Survival Signals by Co-opting the B Cell Receptor Signaling Pathway
Edina Schweighoffer,Lesley Vanes,Josquin Nys,Doreen A. Cantrell,Scott McCleary,Nicholas Smithers,Victor L. J. Tybulewicz +6 more
TL;DR: It is concluded that the BCR and Igα may be required for B cell survival because they function as adaptor proteins in a BAFFR signaling pathway leading to activation of Syk, demonstrating previously unrecognized crosstalk between the two receptors.
Journal ArticleDOI
Discovery of GSK143, a highly potent, selective and orally efficacious spleen tyrosine kinase inhibitor.
John Liddle,Francis Louis Atkinson,Michael David Barker,Paul S. Carter,Neil R. Curtis,Robert P. Davis,Clement Douault,Marion C. Dickson,Dorothy Elwes,Neil Stuart Garton,Matthew Gray,Thomas George Christopher Hayhow,Clare I. Hobbs,Emma J. Jones,Stuart G. Leach,Karen Leavens,Huw D. Lewis,Scott McCleary,Margarete Neu,Vipulkumar Kantibhai Patel,Alex Preston,Cesar Ramirez-Molina,Tracy Jane Shipley,Philip Alan Skone,Nick Smithers,Donald O. Somers,Ann Louise Walker,Robert J. Watson,Gordon G. Weingarten +28 more
TL;DR: The lead optimisation of the diaminopyrimidine carboxamide series of spleen tyrosine kinase inhibitors is described, with GSK143 is a potent and highly selective SYK inhibitor showing good efficacy in the rat Arthus model.
Journal ArticleDOI
Syk Tyrosine Kinase Is Critical for B Cell Antibody Responses and Memory B Cell Survival
Jochen A. Ackermann,Josquin Nys,Edina Schweighoffer,Scott McCleary,Nicholas Smithers,Victor L. J. Tybulewicz +5 more
TL;DR: It is shown that Syk-deficient primary mouse B cells have a severe defect in BCR-induced activation, proliferation, and survival, and that the survival of existing memory B cells is dependent on Syk.
Journal ArticleDOI
Discovery of a Novel Bromodomain and Extra Terminal Domain (BET) Protein Inhibitor, I-BET282E, Suitable for Clinical Progression.
Katherine Louise Jones,Dominic M. Beaumont,Sharon G. Bernard,Rino A. Bit,Simon P. Campbell,Chun-wa Chung,Leanne Cutler,Emmanuel Hubert Demont,Kate Dennis,Laurie J. Gordon,James Gray,Michael V. Haase,Antonia J. Lewis,Scott McCleary,Darren Jason Mitchell,Susanne M. Moore,Nigel J. Parr,Olivia J. Robb,Nicholas Smithers,Peter Ernest Soden,Colin J. Suckling,Simon Taylor,Ann Louise Walker,Robert J. Watson,Rab K. Prinjha +24 more
TL;DR: In this paper, the structure and property-based optimization of the in vivo tool molecule I-BET151 toward the Bromodomain and extra terminal (BET) family of proteins is described.