Macrophages display remarkable plasticity and can change their physiology in response to environmental cues. These changes can give rise to different populations of cells with distinct functions. In this Review we suggest a new grouping of macrophage populations based on three different homeostatic activities - host defence, wound healing and immune regulation. We propose that similarly to primary colours, these three basic macrophage populations can blend into various other 'shades' of activation. We characterize each population and provide examples of macrophages from specific disease states that have the characteristics of one or more of these populations.

/pdf/exploring-the-full-spectrum-of-macrophage-activation-b5rnrcgcen.pdf

Exploring the full spectrum of macrophage activation.

BackgroundPembrolizumab is a humanized monoclonal antibody against programmed death 1 (PD-1) that has antitumor activity in advanced non–small-cell lung cancer (NSCLC), with increased activity in tumors that express programmed death ligand 1 (PD-L1). MethodsIn this open-label, phase 3 trial, we randomly assigned 305 patients who had previously untreated advanced NSCLC with PD-L1 expression on at least 50% of tumor cells and no sensitizing mutation of the epidermal growth factor receptor gene or translocation of the anaplastic lymphoma kinase gene to receive either pembrolizumab (at a fixed dose of 200 mg every 3 weeks) or the investigator’s choice of platinum-based chemotherapy. Crossover from the chemotherapy group to the pembrolizumab group was permitted in the event of disease progression. The primary end point, progression-free survival, was assessed by means of blinded, independent, central radiologic review. Secondary end points were overall survival, objective response rate, and safety. ResultsMedi...

https://www.nejm.org/doi/suppl/10.1056/NEJMoa1606774/suppl_file/nejmoa1606774_protocol.pdf

Pembrolizumab versus Chemotherapy for PD-L1–Positive Non–Small-Cell Lung Cancer

Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications

Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes

CA : A Cancer Journal for Clinicians

The prognostic influence of tumour-infiltrating lymphocytes in cancer: a systematic review with meta-analysis

/pdf/the-prognostic-influence-of-tumour-infiltrating-lymphocytes-1htzr167eu.pdf

Surface modification of nanoparticles to oppose uptake by the mononuclear phagocyte system

Liposomes in the Therapy of Infectious Disease and Cancer

Cells of the hepatic sinusoid

Purpose
Ovarian cancer patients with intra-tumoral CD3+ T-lymphocytes in primary tumor tissue have a better prognosis. This study aims to analyze the presence and relative influence of three important T-lymphocyte subsets, tumor-infiltrating CD8+ cytotoxic T-lymphocytes (CTL), CD45R0+ memory T-lymphocytes, and FoxP3+ regulatory T-lymphocytes (Treg), in primary tumor tissue and omental metastases of patients with ovarian cancer.

/pdf/prognostic-significance-of-tumor-infiltrating-t-lymphocytes-2587j7bsu2.pdf

Toos Daemen

Papers

The prognostic influence of tumour-infiltrating lymphocytes in cancer: a systematic review with meta-analysis

Surface modification of nanoparticles to oppose uptake by the mononuclear phagocyte system

Liposomes in the Therapy of Infectious Disease and Cancer

Cells of the hepatic sinusoid

Prognostic significance of tumor-infiltrating T-lymphocytes in primary and metastatic lesions of advanced stage ovarian cancer.