T
Toshihiko Kuroiwa
Researcher at Tokyo Medical and Dental University
Publications - 151
Citations - 3314
Toshihiko Kuroiwa is an academic researcher from Tokyo Medical and Dental University. The author has contributed to research in topics: Ischemia & Cerebral blood flow. The author has an hindex of 29, co-authored 151 publications receiving 3155 citations.
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Journal ArticleDOI
Left ventricular wall motion abnormalities in patients with subarachnoid hemorrhage: Neurogenic stunned myocardium☆
Tatsuji Kono,Hiroshi Morita,Toshihiko Kuroiwa,Haruhiko Onaka,Hiroyuki Takatsuka,Akira Fujiwara +5 more
TL;DR: It is suggested that patients with subarachnoid hemorrhage and ST segment elevation may demonstrate transient corresponding regional wall motion abnormalities in the form of neurogenic stunned myocardium.
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Human neural stem/progenitor cells, expanded in long‐term neurosphere culture, promote functional recovery after focal ischemia in Mongolian gerbils
Satoru Ishibashi,Masanori Sakaguchi,Toshihiko Kuroiwa,Mami Yamasaki,Yonehiro Kanemura,Ichinose Shizuko,Takuya Shimazaki,Masafumi Onodera,Hideyuki Okano,Hidehiro Mizusawa +9 more
TL;DR: Human NSPCs, even from long‐term culture, remarkably improved neurologic functions after focal ischemia in the Mongolian gerbil, and maintained their abilities to migrate around the infarction, differentiate into mature neurons, and form synapses with host neuronal circuits.
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Modified boron neutron capture therapy for malignant gliomas performed using epithermal neutron and two boron compounds with different accumulation mechanisms: an efficacy study based on findings on neuroimages.
Shin-Ichi Miyatake,Shinji Kawabata,Yoshinaga Kajimoto,Atsushi Aoki,Kunio Yokoyama,Makoto Yamada,Toshihiko Kuroiwa,Motomu Tsuji,Yoshio Imahori,Mitsunori Kirihata,Yoshinori Sakurai,Shin-ichiro Masunaga,Kenji Nagata,Akira Maruhashi,Koji Ono +14 more
TL;DR: This modified BNCT produced a good improvement in malignant gliomas, as seen on neuroimages, and more than 50% of the contrast-enhanced lesions disappeared in eight of the 12 patients during the follow-up period.
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Blood-brain barrier disruption and exacerbation of ischemic brain edema after restoration of blood flow in experimental focal cerebral ischemia.
TL;DR: The study indicated that the increase of extracellular osmotic pressure due to leakage of serum proteins via the disrupted BBB and of intracellular substances via the ischemically injured cell membrane into the extacellular space is the mechanism responsible for edema fluid accumulation in exacerbated ischemic brain edema.
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Experimental neurotoxicity of 5-fluorouracil and its derivatives is due to poisoning by the monofluorinated organic metabolites, monofluoroacetic acid and alpha-fluoro-beta-alanine.
TL;DR: It was concluded that the subacute and chronic neurotoxicity of FU and its derivatives in dogs and cats is due to intoxication with the monofluorinated organic metabolites, FA and FBAL, and that the direct action of FA andFBAL on myelin and the action of FBAL on energy metabolism or vessels of the mid brain were proposed as the main pathogenetic factor involved.