T
Toshio Kawahara
Publications - 4
Citations - 3118
Toshio Kawahara is an academic researcher. The author has contributed to research in topics: Rho kinase inhibitor & Rho-associated protein kinase. The author has an hindex of 3, co-authored 4 publications receiving 3029 citations.
Papers
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Journal ArticleDOI
Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension
Masayoshi Uehata,Toshimasa Ishizaki,Hiroyuki Satoh,Takashi Ono,Toshio Kawahara,Tamami Morishita,Hiroki Tamakawa,Keiji Yamagami,Jun Inui,Midori Maekawa,Shuh Narumiya +10 more
TL;DR: Pyridine derivative Y-27632 consistently suppresses Rho-induced, p160ROCK-mediated formation of stress fibres in cultured cells and dramatically corrects hypertension in several hypertensive rat models, suggesting that compounds that inhibit this process might be useful therapeutically.
Patent
MEDICINES COMPRISING Rho KINASE INHIBITOR
TL;DR: Novel medicines comprising Rho kinase inhibitors, such as hypertension remedy, angina remedy, cerebrovascular twitching inhibitor, asthma remedy, premature birth preventive, arteriosclerosis remedy, anticancer drug, anti-phlogistic, immunosuppressive, autoimmune disease remedy, anti AIDS drug, contraceptive, digestive infection preventive, osteoporosis remedy, retinopathy remedy, and cerebral function ameliorant.
Patent
Pharmaceutical agent containing Rho kinase inhibitor
TL;DR: In this paper, a Rho kinase inhibitor is provided as a novel pharmaceutical agent, particularly as a therapeutic agent of hypertension, a therapeutic agents of angina pectoris, a suppressive agent of cerebrovascular contraction.
Patent
MEDICAMENTS COMPRENANT UN INHIBITEUR DE LA Rho KINASE
TL;DR: In this paper, the authors propose des nouveaux medicaments comprenant des inhibiteurs de la Rho kinase, utilises comme remedes contre l'hypertension, contre theangine, inhibiteur des secousses musculaire cerebrovasculaires, remede contre la retinopathie and agent ameliorant la fonction cerebrale.