T
Tracee L. McMiller
Researcher at Johns Hopkins University School of Medicine
Publications - 20
Citations - 16283
Tracee L. McMiller is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Immune system & Melanoma. The author has an hindex of 12, co-authored 18 publications receiving 14211 citations. Previous affiliations of Tracee L. McMiller include Johns Hopkins University.
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Journal ArticleDOI
Safety, activity, and immune correlates of anti-PD-1 antibody in cancer.
Suzanne L. Topalian,F. Stephen Hodi,Julie R. Brahmer,Scott N. Gettinger,David Smith,David F. McDermott,John D. Powderly,Richard D. Carvajal,Jeffrey A. Sosman,Michael B. Atkins,Philip D. Leming,David R. Spigel,Scott J. Antonia,Leora Horn,Charles G. Drake,Drew M. Pardoll,Lieping Chen,William H. Sharfman,Robert A. Anders,Janis M. Taube,Tracee L. McMiller,Haiying Xu,Alan J. Korman,Maria Jure-Kunkel,Shruti Agrawal,Dan McDonald,Georgia Kollia,Ashok Kumar Gupta,Jon M. Wigginton,Mario Sznol +29 more
TL;DR: Anti-PD-1 antibody produced objective responses in approximately one in four to one in five patients with non-small-cell lung cancer, melanoma, or renal-cell cancer; the adverse-event profile does not appear to preclude its use.
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Phase I Study of Single-Agent Anti–Programmed Death-1 (MDX-1106) in Refractory Solid Tumors: Safety, Clinical Activity, Pharmacodynamics, and Immunologic Correlates
Julie R. Brahmer,Charles G. Drake,Ira Wollner,John D. Powderly,Joel Picus,William H. Sharfman,Elizabeth Stankevich,Alice Pons,Theresa M. Salay,Tracee L. McMiller,Marta M. Gilson,Changyu Wang,Mark J. Selby,Janis M. Taube,Robert A. Anders,Lieping Chen,Alan J. Korman,Drew M. Pardoll,Israel Lowy,Suzanne L. Topalian +19 more
TL;DR: Blocking the PD-1 immune checkpoint with intermittent antibody dosing is well tolerated and associated with evidence of antitumor activity, and tumor cell surface B7-H1 expression appeared to correlate with the likelihood of response to treatment.
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Colocalization of Inflammatory Response with B7-H1 Expression in Human Melanocytic Lesions Supports an Adaptive Resistance Mechanism of Immune Escape
Janis M. Taube,Robert A. Anders,Geoffrey D. Young,Haiying Xu,Rajni Sharma,Tracee L. McMiller,Shuming Chen,Alison P. Klein,Drew M. Pardoll,Suzanne L. Topalian,Lieping Chen,Lieping Chen +11 more
TL;DR: Induction of the B7-H1/PD-1 pathway may represent an adaptive immune resistance mechanism exerted by tumor cells in response to endogenous antitumor activity and may explain how melanomas escape immune destruction despite endogenous antitUMor immune responses.
Journal ArticleDOI
Mechanisms regulating PD-L1 expression on tumor and immune cells.
Shuming Chen,George A. Crabill,Theresa S. Pritchard,Tracee L. McMiller,Ping Wei,Drew M. Pardoll,Fan Pan,Suzanne L. Topalian +7 more
TL;DR: Understanding complex mechanisms underlying PD-L1 display in the TME may allow treatment approaches mitigating expression of this immunosuppressive ligand, to enhance the impact of PD-1 blockade.
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Differential Expression of Immune-Regulatory Genes Associated with PD-L1 Display in Melanoma: Implications for PD-1 Pathway Blockade
Janis M. Taube,Geoffrey D. Young,Tracee L. McMiller,Shuming Chen,January T. Salas,Theresa S. Pritchard,Haiying Xu,Alan K. Meeker,Jinshui Fan,Chris Cheadle,Alan E. Berger,Drew M. Pardoll,Suzanne L. Topalian +12 more
TL;DR: Functional annotation clustering based on whole-genome expression profiling revealed pathways upregulated in PD-L1+ melanomas, involving immune cell activation, inflammation, and antigen processing and presentation, which elucidate the complexity of immune checkpoint regulation in the tumor microenvironment.