C
Chris Cheadle
Researcher at Johns Hopkins University School of Medicine
Publications - 70
Citations - 5669
Chris Cheadle is an academic researcher from Johns Hopkins University School of Medicine. The author has contributed to research in topics: Gene expression & Regulation of gene expression. The author has an hindex of 36, co-authored 69 publications receiving 5064 citations. Previous affiliations of Chris Cheadle include Johns Hopkins University & National Institutes of Health.
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Journal ArticleDOI
Analysis of Microarray Data Using Z Score Transformation
TL;DR: It is concluded that the Z score transformation normalization method accompanied by either Z ratios or Z tests for significance estimates offers a useful method for the basic analysis of microarray data.
Journal ArticleDOI
Tight junction defects in patients with atopic dermatitis.
Anna De Benedetto,Nicholas Rafaels,Laura Y. McGirt,Andrei I. Ivanov,Steve N. Georas,Chris Cheadle,Alan E. Berger,Kunzhong Zhang,Sadasivan Vidyasagar,Takeshi Yoshida,Mark Boguniewicz,Tissa Hata,Lynda C. Schneider,Jon M. Hanifin,Richard L. Gallo,Natalija Novak,Stephan Weidinger,Terri H. Beaty,Donald Y.M. Leung,Kathleen C. Barnes,Lisa A. Beck +20 more
TL;DR: It is suggested that an impairment in tight junctions contributes to the barrier dysfunction and immune dysregulation observed in AD subjects and that this may be mediated in part by reductions in claudin-1.
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The Local and Systemic Inflammatory Transcriptome after Acute Kidney Injury
Dmitry N. Grigoryev,Manchang Liu,Heitham T. Hassoun,Chris Cheadle,Kathleen C. Barnes,Hamid Rabb +5 more
TL;DR: This is the first comprehensive analysis of concomitant inflammation-associated transcriptional changes in the kidney and a remote organ during AKI, suggesting that this type of analysis may be a useful discovery tool for novel biomarkers and therapeutic drug development.
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Differential Expression of Immune-Regulatory Genes Associated with PD-L1 Display in Melanoma: Implications for PD-1 Pathway Blockade
Janis M. Taube,Geoffrey D. Young,Tracee L. McMiller,Shuming Chen,January T. Salas,Theresa S. Pritchard,Haiying Xu,Alan K. Meeker,Jinshui Fan,Chris Cheadle,Alan E. Berger,Drew M. Pardoll,Suzanne L. Topalian +12 more
TL;DR: Functional annotation clustering based on whole-genome expression profiling revealed pathways upregulated in PD-L1+ melanomas, involving immune cell activation, inflammation, and antigen processing and presentation, which elucidate the complexity of immune checkpoint regulation in the tumor microenvironment.
Journal ArticleDOI
PubMatrix: a tool for multiplex literature mining
Kevin G. Becker,Douglas A. Hosack,Glynn Dennis,Richard A. Lempicki,Tiffani J Bright,Chris Cheadle,James Engel +6 more
TL;DR: PubMatrix is a web-based tool that allows simple text based mining of the NCBI literature search service PubMed using any two lists of keywords terms, resulting in a frequency matrix of term co-occurrence, which can be assigned genetic, biological, or clinical relevance in a rapid flexible systematic fashion.