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Tracy McLellan
Researcher at University of Utah
Publications - 4
Citations - 268
Tracy McLellan is an academic researcher from University of Utah. The author has contributed to research in topics: Gel electrophoresis & Polyacrylamide gel electrophoresis. The author has an hindex of 4, co-authored 4 publications receiving 258 citations.
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Journal ArticleDOI
Electrophoresis buffers for polyacrylamide gels at various pH.
TL;DR: Continuous electrophoresis buffers are described for polyacrylamide gels at pH values ranging from 3.8 to 10.2 and are likely to be useful in the detection of genetic variation in proteins and in other applications.
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Molecular Charge and Electrophoretic Mobility in Cetacean Myoglobins of Known Sequence
TL;DR: Examination of myoglobins by gel electrophoresis at a wide range of pH values allows discrimination of nearly all amino acid substitutions and demonstrates the close relationship between titration and relative electrophoretic mobility.
Journal ArticleDOI
Genetic variation in proteins: comparison of one-dimensional and two-dimensional gel electrophoresis
TL;DR: The application of two-dimensional electrophoresis to the measurement of genetic variation and to the detection of new mutations should be made carefully, in view of the limited sensitivity of the method in finding differences in sequence.
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The sensitivity of isoelectric focusing and electrophoresis in the detection of sequence differences in proteins.
Tracy McLellan,Lisa S. Inouye +1 more
TL;DR: Only major charge differences, resulting from the changes in the total numbers of acidic and basic amino acids, can be detected on gels with urea, indicating that denaturation by urea alters proteins so that small differences in ionization are eliminated.