Trudy L. Bush

TL;DR: There was no conclusive evidence that it reflected an association between baseline cholesterol and loss to follow-up, although this flattening of the age trend was suggestive.

TL;DR: The fundamental philosophical question of whether large numbers of healthy women should be "treated" with a toxic drug for the primary prevention of a rare event remains.

TL;DR: Meta-analyses, which overcome type II error, have not demonstrated an association between ERT and risk of breast cancer and in general, prospective studies are preferable to case-control studies, however, there are problems with all studies, including prospective ones.

TL;DR: The mathematical method used to calculate fractions of E2 is valid, and RR analyses using calculated values produce similar results to those using measured values, which suggests that for epidemiological studies, it is only necessary to measure total E2 concentration and SHBG concentration, with hormone fractions being obtained by calculation, producing savings in cost, time, and serum.

TL;DR: Since cardiovascular disease is the major cause of morbidity and mortality in postmenopausal women, and since the beneficial effects of estrogen outweigh the documented and perceived risk of estrogen use, estrogen ought to be considered as prophylactic therapy, particularly in women at risk of heart disease.