T
Tsuyoshi Aoki
Researcher at Kyushu University
Publications - 3
Citations - 1548
Tsuyoshi Aoki is an academic researcher from Kyushu University. The author has contributed to research in topics: Protein kinase C & Oxidative stress. The author has an hindex of 3, co-authored 3 publications receiving 1465 citations.
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High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C--dependent activation of NAD(P)H oxidase in cultured vascular cells.
Toyoshi Inoguchi,Ping Li,Fumio Umeda,Hai Yan Yu,Maiko Kakimoto,Minako Imamura,Tsuyoshi Aoki,Takashi Etoh,Toshihiko Hashimoto,Masaichi Naruse,Hiroaki Sano,Hideo Utsumi,Hajime Nawata +12 more
TL;DR: Both high glucose level and palmitate may stimulate ROS production through PKC-dependent activation of NAD(P)H oxidase in both vascular SMCs and ECs, which may be involved in the excessive acceleration of atherosclerosis in patients with diabetes and insulin resistance syndrome.
Journal ArticleDOI
Chronic Sulfonylurea Treatment and Hyperglycemia Aggravate Disproportionately Elevated Plasma Proinsulin Levels in Patients with Type 2 Diabetes
Toyoshi Inoguchi,Fumio Umeda,Maiko Kakimoto,Yasuhiro Sako,Hidehiro Ishii,Katsumi Noda,Makoto Kunisaki,Minako Imamura,Hai Yan Yu,Takashi Etoh,Hiroyasu Yoshikawa,Tsuyoshi Aoki,Toshihiko Hashimoto,Hajime Nawata +13 more
TL;DR: Results imply that disproportionate hyperproinsulinemia may reflect an excessive overwork of beta cells under chronic sulfonylurea treatment as well as hyperglycemia in patients with Type 2 diabetes.
Journal ArticleDOI
Force requirements and insulin delivery profiles of four injection devices.
Kenichi Toraishi,Yoichi Yuizono,Noriko Nakamura,Shino Kato,Tsuyoshi Aoki,Kenji Ashida,Yasuhiro Sako +6 more
TL;DR: The InnoLet and NovoPen 3 showed the most even load-displacement curves, suggesting a smoother delivery of insulin during injection, and the results highlight the potential importance of careful pen selection for patients with neuromuscular weakness or impaired manual coordination.