Showing papers by "Tyge Greibrokk published in 1986"
TL;DR: Etude comparative de l'aptitude of l'oxyde azoteux and du dioxyde de carbone dans un etat supercritique a separer les composes chimiques dans les fractions petrolieres a point d'ebullition eleve and dans le petrole brut as mentioned in this paper
26 citations
TL;DR: In this article, a specific, sensitive, and precise assay for simultaneous quantitation of glyceryl trinitrate and its metabolites 1,2-and 1,3-glyceryl dinitrate (GDN) has been developed.
Abstract: A specific, sensitive, and precise assay for simultaneous quantitation of glyceryl trinitrate (GTN) and its metabolites 1,2-and 1,3-glyceryl dinitrate (GDN) has been developed. The method involves one single extraction step with benzene, followed by evaporation at 55°C. One μl of the extract was injected onto a capillary fused silica column with trifluoropropyl as the stationary phase. The column separated all the nitrates within 17 minutes using temperature programming from 90 to 155°C. The lower limits of detection were 0.05, 0.5, and 0.1 nmol/I for GTN, 1,2-GDN and 1,3-GDN respectively. The calibration curves were linear in the concentration ranges 0.05–10.0 nmol/I (GTN), 0.5–10.0 nmol/I (1,2-GDN) and 0.1–10.0 nmol/I (1,3-GDN). Plasma concentration data from two patients receiving intravenous GTN infusion are presented.
3 citations