U. Hauser

TL;DR: Investigating a possibly distinct cytokine and chemokine pattern that could explain the characteristic tissue eosinophilia in nasal polyps indicates that IL-5 plays a key role in the pathophysiology of eOSinophilic nasalpolyps and may be produced by eos inophils.

TL;DR: The limited success of detection of new tumor manifestations in terms of survival does not justify a reduction in tumor-follow-up examinations, but follow-up efforts should concentrate on detection of locoregional recurrence, particularly if an option for further curative local therapy exists.

TL;DR: EMD 72 000 was very well tolerated in patients with advanced stage SCCHN and the pharmacokinetic data from this trial suggest the feasibility of conducting future studies with weekly doses of 200 mg EMD 72-000.

TL;DR: It is suggested that molecular events resulting in the inactivation of the p53 pathway occur in all HNSCC cell lines, however, single alterations in the p 53 pathway are not reliable predictors for the response to radio- or chemotherapy in H NSCC.

TL;DR: In an in vitro assay using fresh nasal mucosa of grass-pollen-allergic subjects, a strong and rapid induction of E-selectin adhesion receptor expression on endothelial cells by allergen, IL-1 beta and TNF is demonstrated.