U
U. I. Walther
Researcher at Ludwig Maximilian University of Munich
Publications - 25
Citations - 721
U. I. Walther is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Glutathione & Zinc toxicity. The author has an hindex of 15, co-authored 25 publications receiving 699 citations.
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Journal ArticleDOI
In vitro embryotoxicity assessment with dental restorative materials.
S. Schwengberg,H. Bohlen,Norbert Kleinsasser,Kai Kehe,Mario Seiss,U. I. Walther,Reinhard Hickel,Franz-Xaver Reichl +7 more
TL;DR: BisGMA induced a significant high embryotoxic/teratogenic effect over a large range of concentration, and attention should be focused on this dental monomer, which should be investigated further by in vivo experiments.
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Antioxidative vitamins decrease cytotoxicity of HEMA and TEGDMA in cultured cell lines.
TL;DR: The postulated mechanism of HEMA or TEGDMA toxicity based on radical metabolites is supported by the effectivity of the antioxidative substances tested in mitigating toxicity and by the greater susceptibility of the glutathione redox system as compared to protein synthesis inhibition in assessing toxicity.
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Are we ready to replace dimercaprol (BAL) as an arsenic antidote
TL;DR: The results show that hydrophilic DMPS and DMSA may fail to rapidly and completely remove arsenic that has escaped from the extracellular space across tight epithelial barriers, but owing to their low toxicity, which allows larger doses to be applied, and the potential modification of their pharmacokinetics by means of inert oral anion-exchange resins,DMPS andDMSA may advantageously replace BAL when ever intervention time is not critical.
Journal ArticleDOI
Cytotoxicity of dental composite components and mercury compounds in lung cells.
Franz-Xaver Reichl,U. I. Walther,Jürgen Durner,Kai Kehe,Reinhard Hickel,Karl-Heinz Kunzelmann,W. Spahl,Wyatt R. Hume,H.P. Benschop,W. Forth +9 more
TL;DR: The toxic effect of HgCl2 and MeHgCl from the L2 cells was about 100-700-fold higher than of the dental composite components and a significant time dependent increase of toxicity was observed with TEGDMA, HEMA and MehgCl.
Journal ArticleDOI
Cytotoxicity of dental composite components and mercury compounds in pulmonary cells.
TL;DR: It is to be assumed that the risk of lung cell damage by dental composite components is even more unlikely.