U
Ulrike B. Zeilhofer
Researcher at University of Zurich
Publications - 3
Citations - 574
Ulrike B. Zeilhofer is an academic researcher from University of Zurich. The author has contributed to research in topics: Nociception & GABAA receptor. The author has an hindex of 3, co-authored 3 publications receiving 546 citations. Previous affiliations of Ulrike B. Zeilhofer include University of Erlangen-Nuremberg.
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Journal ArticleDOI
Reversal of pathological pain through specific spinal GABAA receptor subtypes.
Julia Knabl,Robert Witschi,Katharina Hösl,Heiko Reinold,Ulrike B. Zeilhofer,Seifollah Ahmadi,Seifollah Ahmadi,Johannes Brockhaus,Johannes Brockhaus,Marina Sergejeva,Andreas Hess,Kay Brune,Jean-Marc Fritschy,Uwe Rudolph,Uwe Rudolph,Hanns Möhler,Hanns Möhler,Hanns Ulrich Zeilhofer,Hanns Ulrich Zeilhofer,Hanns Ulrich Zeilhofer +19 more
TL;DR: It is shown that their selective activation by the non-sedative (‘α1-sparing’) benzodiazepine-site ligand L-838,417 is highly effective against inflammatory and neuropathic pain yet devoid of unwanted sedation, motor impairment and tolerance development.
Journal ArticleDOI
Genuine antihyperalgesia by systemic diazepam revealed by experiments in GABAA receptor point-mutated mice
Julia Knabl,Ulrike B. Zeilhofer,Ulrike B. Zeilhofer,Florence Crestani,Uwe Rudolph,Hanns Ulrich Zeilhofer,Hanns Ulrich Zeilhofer,Hanns Ulrich Zeilhofer +7 more
TL;DR: It is concluded that systemic diazepam exerts a genuine antihyperalgesic effect, which depends on spinal GABAA receptors containing α2 and/or α3 subunits, which reduced formalin‐induced flinching in wild‐type mice.
Journal ArticleDOI
Spinal dis-inhibition in inflammatory pain.
TL;DR: It is proposed that pathologically heightened pain sensitivity can be reversed by restoring synaptic inhibition with drugs that target specific spinal GABAA receptor subtypes.