Uri Merdler

TL;DR: The importance of establishing mature and complex vessel networks in engineered tissues before implantation to promote anastomosis with the host and accelerate graft perfusion is demonstrated.

TL;DR: In this article, a combination of millimetric vessel-like scaffolds and 3D bioprinted vascularized tissues interconnect, creating fully engineered hierarchical vascular constructs for implantation.

TL;DR: The oriented scaffold was shown to guide regenerating axons to linear conformations and support growth of induced pluripotent stem cell-derived neurons in vitro and in vivo in a model of spinal cord injury and may advance the field of nerve regeneration.

TL;DR: Highly vascularized DPSC‐embedded constructs bear angiogenic and neurotrophic potentials, capable of augmenting and modulating SCI repair, and demonstrate substantial regenerated vessels, more significantly in the sensory tract regions, which correlates with behavioral recovery following prevascularization treatment.

TL;DR: New insight is provided regarding vessel sprouting decisions that should be considered when designing scaffolds for vascularized engineered tissues, especially within 3D environments.