V
V. P. Kukhar
Researcher at National Academy of Sciences of Ukraine
Publications - 10
Citations - 220
V. P. Kukhar is an academic researcher from National Academy of Sciences of Ukraine. The author has contributed to research in topics: Substrate (chemistry) & Schiff base. The author has an hindex of 7, co-authored 10 publications receiving 216 citations.
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General method for the synthesis of enantiomerically pure β-hydroxy-α-amino acids, containing fluorine atoms in the side chains. Case of stereochemical distinction between methyl and trifluoromethyl groups. X-Ray crystal and molecular structure of the nickel(II) complex of (2S,3S)-2(trifluoromethyl)threonine
Vadim A. Soloshonok,V. P. Kukhar,Sergei V. Galushko,Nataly Yu. Svistunova,Dimitri V. Avilov,Nadia A. Kuz'mina,Nicolai I. Raevski,Yuri T. Struchkov,Alexander P. Pysarevsky,Yuri N. Belokon +9 more
TL;DR: In this article, the chiral NiII complex 1 of a Schiff's base derived from (S)-o-[N-(benzylprolyl)amino] benzophenone (BPB) and glycine was treated with fluoro-substituted aldehydes (aliphatic and aromatic) in MeOH or CHCl3.
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Asymmetric Synthesis of Organoelement Analogues of Natural Products; Part 12: General Method for the Asymmetric Synthesis of Fluorine-Containing Phenylalanines and α-Methyl(phenyl)alanines via Alkylation of the Chiral Nickel(II) Schiff's Base Complexes of Glycine and Alanine
V. P. Kukhar,Yuri N. Belokon,Vadim A. Soloshonok,Nataly Yu. Svistunova,Alexander B. Rozhenko,N. A. Kuz'mina +5 more
TL;DR: In this article, a large selectivity (>90%) is observed for the alkylation of both complexes for asymmetric synthesis of fluoro (S)-phenylalanines and α-methyl(phenyl)alanines.
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Enzymatic preparation of both L- and D-enantiomers of phosphonic and phosphonous analogues of alanine using penicillin acylase
V. A. Solodenko,Michail Y. Belik,Sergei V. Galushko,V. P. Kukhar,Elena Kozlova,Elena Kozlova,Dmitri A. Mironenko,Dmitri A. Mironenko,Vitas K. Svedas,Vitas K. Svedas +9 more
TL;DR: In this paper, the same enzyme was used to prepare both L- and D-enantiomers of these phosphorus analogues of alanine by stepwise enzymatic hydrolysis of their racemic N-phenylacetyl derivatives.
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Preparation of N-Acylated Phosphonopeptides with Free Phosphonic Group
TL;DR: Aminoalkylphosphonic acids on heating with hexamethyldisilazane yield tris(trimethylsilyl) derivatives, which are used as amino components for the synthesis of N-acylated phosphonopeptides with free phosphonic group as mentioned in this paper.
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Stereoselective papain-catalyzed synthesis of alafosfalin
V. A. Solodenko,V. P. Kukhar +1 more
TL;DR: Papain in powdered form efficiently catalyzes alafosfalin synthesis in miscible aqueous-organic solvent involving L-aminophosphonate in peptide bond formation.