V
Valérie St-Pierre
Researcher at Université de Sherbrooke
Publications - 22
Citations - 876
Valérie St-Pierre is an academic researcher from Université de Sherbrooke. The author has contributed to research in topics: Glucose uptake & Polyunsaturated fatty acid. The author has an hindex of 11, co-authored 21 publications receiving 540 citations.
Papers
More filters
Journal ArticleDOI
Can ketones compensate for deteriorating brain glucose uptake during aging? Implications for the risk and treatment of Alzheimer's disease.
Stephen C. Cunnane,Alexandre Courchesne-Loyer,Valérie St-Pierre,Camille Vandenberghe,Tyler Pierotti,Mélanie Fortier,Etienne Croteau,Christian-Alexandre Castellano +7 more
TL;DR: Clinical trials demonstrate that increasing ketone availability to the brain via moderate nutritional ketosis has a modest beneficial effect on cognitive outcomes in mild‐to‐moderate AD and in mild cognitive impairment.
Journal ArticleDOI
Can Ketones Help Rescue Brain Fuel Supply in Later Life? Implications for Cognitive Health during Aging and the Treatment of Alzheimer’s Disease
Stephen C. Cunnane,Alexandre Courchesne-Loyer,Camille Vandenberghe,Valérie St-Pierre,Mélanie Fortier,Marie Hennebelle,Etienne Croteau,Christian Bocti,Tamas Fulop,Christian-Alexandre Castellano +9 more
TL;DR: The brain energy deficit needs to be overcome in order to successfully develop more effective therapeutics for Alzheimer’s disease, and oral ketogenic supplements are the most promising means of achieving this goal.
Journal ArticleDOI
A ketogenic drink improves brain energy and some measures of cognition in mild cognitive impairment.
Mélanie Fortier,Christian-Alexandre Castellano,Etienne Croteau,Francis Langlois,Christian Bocti,Valérie St-Pierre,Camille Vandenberghe,Michaël Bernier,Maggie Roy,Maxime Descoteaux,Kevin Whittingstall,Martin Lepage,Eric Turcotte,Tamas Fulop,Stephen C. Cunnane +14 more
TL;DR: Unlike for glucose, uptake of the brain's main alternative fuel, ketones, remains normal in mild cognitive impairment (MCI), but ketogenic medium chain triglycerides could improve cognition in MCI by providing the brain with more fuel.
Journal ArticleDOI
Inverse relationship between brain glucose and ketone metabolism in adults during short-term moderate dietary ketosis: A dual tracer quantitative positron emission tomography study.
Alexandre Courchesne-Loyer,Etienne Croteau,Christian-Alexandre Castellano,Valérie St-Pierre,Marie Hennebelle,Stephen C. Cunnane +5 more
TL;DR: Whether increased ketone availability raises CMR of ketones to the same extent in older people as observed here or in conditions in which chronic brain glucose hypometabolism is present remains to be determined.
Journal ArticleDOI
A ketogenic drink improves cognition in mild cognitive impairment: Results of a 6-month RCT
Mélanie Fortier,Christian-Alexandre Castellano,Valérie St-Pierre,Étienne Myette-Côté,Francis Langlois,Maggie Roy,Marie-Christine Morin,Christian Bocti,Tamas Fulop,Jean-Philippe Godin,Carla Delannoy,Bernard Cuenoud,Stephen C. Cunnane +12 more
TL;DR: Counteracting impaired brain glucose metabolism with ketones may improve cognition in mild cognitive impairment (MCI) and may reduce the risk of long-term memory loss.