Valerio Tomaselli

TL;DR: Evidence is provided that fibroblasts derived from diseased tissue, such as fibrotic lung fibro Blasts, exhibit different functional features compared with normal cells, with particular regard to their modulatory role.

TL;DR: Hemparin was shown to provide protection with respect to nasal allergen challenge, and the mechanism by which heparin produces its protective activity seems to be related to the neutralization of eosinophil cationic protein as well as to the reduction of eOS inophil recruitment.

TL;DR: The reduced Cx43 expression and the associated alteration in cell-to-cell communication may justify some of the known pathological characteristic of this devastating disease that still represents a challenge to the medical practice.

TL;DR: The FCM obtained from fibrotic lung fibroblasts was instead less efficacious in potentiating LPS-stimulated IL-10 release and, consequently, in reducing HLA-DR and CD40 expression, suggesting that an impairment of the immune regulation operated by fibro Blasts may be involved in the maintenance of chronic pulmonary inflammation.

TL;DR: Colocalization of c-erbB receptors and ligands establishes a basis on which to investigate c- DerbB receptor- mediated effects in human nasal epithelium.