D
Daniele F. Condorelli
Researcher at University of Catania
Publications - 180
Citations - 6475
Daniele F. Condorelli is an academic researcher from University of Catania. The author has contributed to research in topics: Gene expression & Glutamate receptor. The author has an hindex of 45, co-authored 171 publications receiving 6091 citations. Previous affiliations of Daniele F. Condorelli include Scuola superiore di Catania.
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Journal ArticleDOI
Cloning of a new gap junction gene (Cx36) highly expressed in mammalian brain neurons
Daniele F. Condorelli,Rosalba Parenti,Francesca Spinella,Angela Trovato Salinaro,Natale Belluardo,Venera Cardile,Federico Cicirata +6 more
TL;DR: It is the first connexin to be expressed predominantly in mammalian neurons and its identification paves the way for a molecular approach in the study of the role played by gap junctions in the physiology and the pathology of the mammalian brain.
Journal ArticleDOI
Expression of connexin36 in the adult and developing rat brain.
Natale Belluardo,Giuseppa Mudò,Angela Trovato-Salinaro,Sabine Le Gurun,Anne Charollais,Véronique Serre-Beinier,Giuseppe Amato,Jacques-Antoine Haefliger,Paolo Meda,Daniele F. Condorelli +9 more
TL;DR: It is found that neuronal cells are responsible for the expression of Cx36 mRNA in inferior olive, cerebellum, striatum, hippocampus and cerebral cortex, and in parvalbumin-containing GABAergic interneurons of cerebral cortex and cerebellar cortex.
Journal ArticleDOI
Functional Properties of Channels Formed by the Neuronal Gap Junction Protein Connexin36
Midituru Srinivas,Renato Rozental,Renato Rozental,Takashi Kojima,Rolf Dermietzel,Mark F. Mehler,Mark F. Mehler,Daniele F. Condorelli,John A. Kessler,John A. Kessler,David C. Spray +10 more
TL;DR: The unique combination of weak voltage sensitivity, small unitary conductance, and permeation by anions as large as second messenger molecules endows Cx36 gap junction channels with properties well suited for mediating flexible electrical and biochemical interactions between neurons.
Journal ArticleDOI
Expression of Cx36 in mammalian neurons.
TL;DR: Evidence in favour of Cx36 predominant expression in neuronal cells in the mammalian central nervous system is summarized, such as results from experiments with specific neurotoxins and co-localization of C x36 mRNA and a neuronal marker.
Journal ArticleDOI
Activation of metabotropic glutamate receptors coupled to inositol phospholipid hydrolysis amplifies NMDA-induced neuronal degeneration in cultured cortical cells.
Valeria Bruno,Agata Copani,Thomas Knöpfel,Rainer Kuhn,G. Casabona,P. Dell' Albani,Daniele F. Condorelli,Ferdinando Nicoletti,Ferdinando Nicoletti +8 more
TL;DR: It is suggested that activation of class I mGluRs enhances NMDA-receptor mediated neuronal toxicity and encourage the search for selective antagonists for the experimental therapy of acute or chronic neurodegenerative diseases.