Showing papers by "Valery M. Dembitsky published in 2015"
TL;DR: This paper tried to analyze anti-breast cancer potencies of quite a few extracts from different plant sources and to compare their anti-proliferative efficiency of crude extracts with actions of their purified ingredients.
Abstract: Upon emergence of modern anticancer therapy, medical community is divided into two opposite camps, one of them claiming absolute necessity of using isolated or synthesized chemical compounds for efficient patient treatment and another one advocating alternative cancer therapies, in particular those based on natural sources, including extracts from plants. It seems, in reality, that the two camps are reconcilable: while natural sources, plant extracts or juices play both curative and protective role, drugs represent the ultimate possibility to inhibit or reverse tumor development. In this paper we tried to analyze anti-breast cancer potencies of quite a few extracts from different plant sources and to compare their anti-proliferative efficiency of crude extracts with actions of their purified ingredients.
61 citations
TL;DR: The role of isoquinoline N-oxides alkaloids as an important source of leads for drug discovery is emphasized and some additional SAR (structure-activity relationship) activities are predicted, which point toward new possible applications of these compounds.
61 citations
TL;DR: Svetlana A. Vizer,† Elena S. Sycheva,† Abed Al Aziz Al Quntar,‡ Nurzhan B. Kurmankulov,† Kazbek B. Yerzhanov,*, and Valery M. Dembitsky are the authors of this paper which aims to demonstrate the efforts towards in-situ applicability of EMT in the context of drug discovery.
Abstract: Svetlana A. Vizer,† Elena S. Sycheva,† Abed Al Aziz Al Quntar,‡ Nurzhan B. Kurmankulov,† Kazbek B. Yerzhanov,† and Valery M. Dembitsky* †A.B. Bekturov Institute of Chemical Sciences, 106 Sh. Walikhanov Street, Almaty 480100, Republic of Kazakhstan ‡Department of Material Engineering, Faculty of Engineering, Al Quds University, Abu Deis 51000, Palestine Institute of Drug Discovery, P.O. Box 45289, Jerusalem 91451, Israel
38 citations
TL;DR: The synthesis, chemical properties, transformations, and biological activities of mono- and multi- substituted cyclobutyl- and cyclobutenylphosphonates were broadly discussed in this article.
Abstract: The synthesis, chemical properties, transformations, and biological activities of mono- and multi- substituted cyclobutyl- and cyclobutenylphosphonates were broadly discussed in this article review. The synthesis of four-membered ring phosphonates was based either on phosphorylation of already constructed cyclobutyl moiety or on inter- and in- tramolecular cyclizations of phosphorus containing compounds. Also, emphasis was illustrated on the recent development in this field.