Showing papers by "Vandana Gupta published in 2006"
TL;DR: Results demonstrate that processing and presentation of N, whether exogenously or endogenously derived, resulted in common immunodominant epitopes, supporting the usefulness of modified antigen delivery and trafficking forms and, in particular, LAMP chimeras as vaccine candidates.
51 citations
TL;DR: It is shown that Msx1 conjugation to SUMO-1 in vivo is enhanced by an E3 SUMO ligase, PIAS1, suggesting that sumoylation ofMsx1 is a new mechanism for modulating the molecular function of MsX1 during organogenesis.
32 citations
TL;DR: It is demonstrated that MIS inhibits androgen-stimulated growth of LNCaP cells and decreases their survival in androgens-deprived medium by preventing cell cycle progression and inducing apoptosis, and these observations suggest that MIS regulates androgynous gene expression and growth in prostate cancer cells through a NFkappaB-dependent but Smad1-independent mechanism.
Abstract: Mullerian inhibiting substance (MIS), a member of the TGFβ superfamily, causes regression of the Mullerian duct in male embryos. The presence of MIS type II and type I receptors in tissues and cell lines derived from the prostate suggests that prostate is a likely target for MIS. In this report, we demonstrate that MIS inhibits androgen-stimulated growth of LNCaP cells and decreases their survival in androgen-deprived medium by preventing cell cycle progression and inducing apoptosis. Expression of dominant-negative Smad1 reversed the ability of MIS to decrease LNCaP cell survival in androgen-deprived medium but not androgen-stimulated growth, whereas abrogation of nuclear factor-κB (NFκB) activation ablated the suppressive effects of MIS on both androgen-stimulated growth and androgen-independent survival. The effect of MIS on androgen-induced growth was not due to changes in androgen receptor expression. However, MIS suppressed androgen-stimulated transcription of prostate-specific antigen; ablation of ...
16 citations