V
Varda Rotter
Researcher at Weizmann Institute of Science
Publications - 289
Citations - 21064
Varda Rotter is an academic researcher from Weizmann Institute of Science. The author has contributed to research in topics: Mutant & Gene. The author has an hindex of 77, co-authored 283 publications receiving 19606 citations. Previous affiliations of Varda Rotter include Hadassah Medical Center & National Institutes of Health.
Papers
More filters
Journal ArticleDOI
When mutants gain new powers: news from the mutant p53 field
Ran Brosh,Varda Rotter +1 more
TL;DR: Recent studies on mutant p53 regulation, gain-of-function mechanisms, transcriptional effects and prognostic association are reviewed, with a focus on the clinical implications of these findings.
Journal ArticleDOI
Mutations in the p53 Tumor Suppressor Gene: Important Milestones at the Various Steps of Tumorigenesis
TL;DR: Interestingly, mutations in the p53 gene were shown to occur at different phases of the multistep process of malignant transformation, thus contributing differentially to tumor initiation, promotion, aggressiveness, and metastasis.
Journal Article
Oncogenic mutations of the p53 tumor suppressor: the demons of the guardian of the genome.
Alex Sigal,Varda Rotter +1 more
TL;DR: Understanding the structure and functions of oncogenic p53 mutants may lead to more potent reactivation modalities or to the ability to eliminate mutant p53 gain of function.
Journal ArticleDOI
Mutant p53 Gain-of-Function in Cancer
Moshe Oren,Varda Rotter +1 more
TL;DR: The biological manifestations of mutant p53 gain-of-function, the underlying molecular mechanisms, and their possible clinical implications are addressed.
Journal ArticleDOI
Major deletions in the gene encoding the p53 tumor antigen cause lack of p53 expression in HL-60 cells
David E. Wolf,Varda Rotter +1 more
TL;DR: It is suggested that the deficiency of the p53 protein in HL-60 cells could have been overcome by using an alternative metabolic pathway, and the c-myc product is a candidate for such an alternative protein.