V
Vassiliki Nikoletopoulou
Researcher at Foundation for Research & Technology – Hellas
Publications - 33
Citations - 2669
Vassiliki Nikoletopoulou is an academic researcher from Foundation for Research & Technology – Hellas. The author has contributed to research in topics: Autophagy & Medicine. The author has an hindex of 13, co-authored 23 publications receiving 2169 citations. Previous affiliations of Vassiliki Nikoletopoulou include University of Basel & University of Lausanne.
Papers
More filters
Journal ArticleDOI
Crosstalk between apoptosis, necrosis and autophagy.
TL;DR: The recent literature that highlights the intricate interplay between apoptosis, necrosis and autophagy is reviewed, focusing on the relevance and impact of this crosstalk in normal development and in pathology.
Journal ArticleDOI
Neurotrophin receptors TrkA and TrkC cause neuronal death whereas TrkB does not
Vassiliki Nikoletopoulou,Heiko Lickert,José María Frade,Chantal Rencurel,Patrizia Giallonardo,Lixin Zhang,Lixin Zhang,Miriam Bibel,Yves-Alain Barde +8 more
TL;DR: It is suggested that the expansion of the Trk gene family that accompanied the segregation of the peripheral from the central nervous system generated a novel mechanism of cell number control, explaining why developing sympathetic and sensory neurons become trophic-factor-dependent for survival.
Journal ArticleDOI
Modulation of Autophagy by BDNF Underlies Synaptic Plasticity
Vassiliki Nikoletopoulou,Kyriaki Sidiropoulou,Emmanouela Kallergi,Yannis Dalezios,Nektarios Tavernarakis,Nektarios Tavernarakis +5 more
TL;DR: It is reported that BDNF signaling via the tropomyosin receptor kinase B (TrkB) and the phosphatidylinositol-3' kinase (PI3K)/Akt pathway suppresses autophagy in vivo, and it is demonstrated that suppression ofAutophagy is required for BDNF-induced synaptic plasticity and for memory enhancement under conditions of nutritional stress.
Journal ArticleDOI
Autophagy in the physiology and pathology of the central nervous system.
Vassiliki Nikoletopoulou,M-E Papandreou,M-E Papandreou,Nektarios Tavernarakis,Nektarios Tavernarakis +4 more
TL;DR: Emerging evidence is presented indicating that constitutive autophagic fluxin neurons has essential roles in key neuronal processes under physiological conditions, and how perturbations of the autophile pathway may underlie diverse pathological phenotypes in neurons associated with neurodevelopmental and neurodegenerative diseases are discussed.
Journal ArticleDOI
Death of developing neurons: New insights and implications for connectivity
TL;DR: Findings indicate that the survival of most neurons in the central nervous system (CNS) is not simply regulated by single growth factors like in the PNS, and components of the cell death machinery have begun to be recognized as regulators of selective axonal degeneration and synaptic function, thus playing a critical role in wiring up the nervous system.