V
Veerle Smits
Publications - 1
Citations - 529
Veerle Smits is an academic researcher. The author has contributed to research in topics: Frontotemporal lobar degeneration & Amyotrophic lateral sclerosis. The author has an hindex of 1, co-authored 1 publications receiving 488 citations.
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TDP-43 transgenic mice develop spastic paralysis and neuronal inclusions characteristic of ALS and frontotemporal lobar degeneration
Hans Wils,Gernot Kleinberger,Jonathan Janssens,Sandra Pereson,Geert Joris,Ivy Cuijt,Veerle Smits,Chantal Ceuterick-de Groote,Christine Van Broeckhoven,Samir Kumar-Singh +9 more
TL;DR: A dose-dependent degeneration of cortical and spinal motor neurons and development of spastic quadriplegia reminiscent of ALS are shown and findings suggest that ≈25-kDa TDP-43 CTFs are noxious to neurons by a gain of aberrant nuclear function.