V
Velimir N. Šimičević
Researcher at University of Zagreb
Publications - 16
Citations - 310
Velimir N. Šimičević is an academic researcher from University of Zagreb. The author has contributed to research in topics: Endoscopic retrograde cholangiopancreatography & Octreotide acetate. The author has an hindex of 7, co-authored 16 publications receiving 293 citations.
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Journal ArticleDOI
A new gastric juice peptide, BPC. An overview of the stomach-stress-organoprotection hypothesis and beneficial effects of BPC
Predrag Sikiric,Marijan Petek,Rudolf Rucman,Sven Seiwerth,Zeljko Grabarevic,Ivo Rotkvić,Branko Turkovic,Vjekoslav Jagić,Boris Mildner,Marko Duvnjak,Nada Lang,Z. Danilović,A. Cviko,M. Kolega,Ahmet Sallmani,S. Djačić,Miljenko Bura,Tomislav Brkić,Marko Banić,Milan Dodig,V. Corić,Velimir N. Šimičević,Marija Veljača,Damir Erceg,Damir Ježek,L.J. Simunić-Banek,N. Skroza,Krešimir Bulić,Gojko Buljat,Miroslav Hanževački,V. Orihovac,Dražen Lučinger,Josip Čulig,Jadranka Separovic,Anton Marovic,Stjepan Mise,Ernest Suchanek,Wendy Matoz,Darko Perović,Miroslav Gjurašin,S. Mikulandra,K. Derniković,V. Cuk,I. Karakas +43 more
TL;DR: BPC, as a possible endogenous free radical scavenger and organoprotection mediator, could be a useful prototype of a new class of drugs, organoprotsective agents.
Journal ArticleDOI
Hepatoprotective effect of BPC 157, a 15-aminoacid peptide, on liver lesions induced by either restraint stress or bile duct and hepatic artery ligation or CCl4 administration. A comparative study with dopamine agonists and somatostatin
Predrag Sikiric,Sven Seiwerth,Zeljko Grabarevic,Rudolf Rucman,Marijan Petek,Ivo Rotkvić,Branko Turkovic,Vjekoslav Jagić,Boris Mildner,Marko Duvnjak,Z. Danilović,M. Kolega,Ahmet Sallmani,Sanja Dacic,Milan Dodig,Nada Lang,Jadranka Separovic,V. Corić,Velimir N. Šimičević,Krešimir Bulić,Marija Veljača,Nevena Skroza,Marko Banić,Tomislav Brkić,Gojko Buljat,Stjepan Mise,Drazen Lucinger,Miljenko Bura +27 more
TL;DR: The hepatoprotective effects of a newly synthesized 15 amino acid fragment code named BPC 157 significantly prevented the development of liver necrosis or fatty changes in rats subjected to 24 h bile duct + hepatic artery ligation, 48 h-restraint stress and CCl4 administration.
Journal ArticleDOI
Pentadecapeptide BPC 157 positively affects both non-steroidal anti-inflammatory agent-induced gastrointestinal lesions and adjuvant arthritis in rats.
Predrag Sikiric,Sven Seiwerth,Zeljko Grabarevic,Rudolf Rucman,Marijan Petek,Vjekoslav Jagić,Branko Turkovic,Ivo Rotkvić,Stjepan Mise,Ivan Zoricic,Paško Konjevoda,Darko Perović,Velimir N. Šimičević,Jadranka Separovic,M. Hanzevacki,Danica Galešić Ljubanović,Branka Artuković,Mirna Bratulić,Marina Tišljar,B Rekic,Miroslav Gjurašin,Pavle Miklić,Gojko Buljat +22 more
TL;DR: In the adjuvant arthritis studies, the lesion's development seems to be considerably reduced after single pentadecapeptide medication, and even more attenuated in rats daily treated with BPC 157, likely pointing to a special anti-inflammatory and mucosal integrity protective effect.
Journal ArticleDOI
The effect of pentadecapeptide BPC 157 on inflammatory, non-inflammatory, direct and indirect pain and capsaicin neurotoxicity
P Sikiric,K. Gyires,Sven Seiwerth,Z. GrabarevlĆ,Rudolf Rucman,Marijan Petek,Ivo Rotkvić,Branko Turkovic,I. UdoviČĆ,Vjekoslav Jagić,Boris Mildner,Marko Duvnjak,Z. Danilović,M. Kolega,Ahmet Sallmani,S. Djačić,M. Hanzevacki,Nada Lang,Velimir N. Šimičević,Marija Veljača,V. Orihovac,Marko Banić,Tomislav Brkić,Gojko Buljat,Darko Perović,Stjepan Mise,A. MarovlĆ,Jadranka Separovic,V. Corić,Krešimir Bulić,A. Cviko,Miljenko Bura +31 more
TL;DR: The anti-nociceptive effects of a newly synthesized pentadecapeptide coded BPC 157 (an essential fragment of new organoprotective gastric juice peptide BPC) was evaluated in comparison with aspirin and morphine reference standards, in various experimental models of indirect/direct nociception and neurotoxicity.
Journal Article
Use of octreotide-acetate in preventing pancreatitis-like changes following therapeutic endoscopic retrograde cholangiopancreatography.
Marko Duvnjak,Supanc,Velimir N. Šimičević,Davor Hrabar,Branko Troskot,Lea Smirčić-Duvnjak,Miroslav Bekavac-Bešlin +6 more
TL;DR: The results obtained in this study seem to indicate that octreotide could prevent the increase in serum pancreatic enzymes, but no significant difference was observed in the prevention of post-ERCP pancreatitis.