V
Vera Regitz-Zagrosek
Researcher at Humboldt State University
Publications - 39
Citations - 1451
Vera Regitz-Zagrosek is an academic researcher from Humboldt State University. The author has contributed to research in topics: Angiotensin II receptor type 1 & Angiotensin II. The author has an hindex of 21, co-authored 38 publications receiving 1409 citations.
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Journal ArticleDOI
Mutation spectrum in a large cohort of unrelated consecutive patients with hypertrophic cardiomyopathy
Jeanette Erdmann,S Daehmlow,S Wischke,M Senyuva,U Werner,J Raible,N Tanis,S Dyachenko,Manfred Hummel,Roland Hetzer,Vera Regitz-Zagrosek +10 more
TL;DR: In this article, single-strand conformation polymorphism analysis was used for mutation screening, followed by DNA-sequencing, and a total of 34 different mutations were identified in 108 patients: 18 mutations in MYBPC3 in 20 patients, 13 missense mutations in myH7 in 14 patients, and one amino acid change in TPM1, TNNT2, and TNNI3, respectively.
Journal ArticleDOI
Angiotensin II–Induced Leukocyte Adhesion on Human Coronary Endothelial Cells Is Mediated by E-Selectin
Michael Gräfe,Wolfgang Auch-Schwelk,Andreas Zakrzewicz,Vera Regitz-Zagrosek,Petra Bartsch,Kristof Graf,Matthias Loebe,Peter Gaehtgens,Eckart Fleck +8 more
TL;DR: It is suggested that AT1 receptors mediate the effects of angiotensin II on E-selectin expression and leukocyte adhesion on coronary endothelial cells.
Journal ArticleDOI
Angiotensin II directly increases transforming growth factor β1 and osteopontin and indirectly affects collagen mRNA expression in the human heart
Claudio Kupfahl,Daniel Pink,Katharina Friedrich,Heinz R Zurbrügg,Michael Neuss,Christina Warnecke,Jens Fielitz,Kristof Graf,Eckart Fleck,Vera Regitz-Zagrosek +9 more
TL;DR: In the human heart, Ang II does not directly increase collagen or fibronectin mRNA, but it does increase TGFbeta-1 and osteopontin mRNA expression.
Journal ArticleDOI
Spectrum of clinical phenotypes and gene variants in cardiac myosin-binding protein C mutation carriers with hypertrophic cardiomyopathy
Jeanette Erdmann,Jörg Raible,Jaleh Maki-Abadi,Jan Hammann,Bernd Wollnik,Eckart Frantz,Eckart Fleck,Vera Regitz-Zagrosek,Manfred Hummel,Roland Hetzer +9 more
TL;DR: Protein truncation mutations seem to cause a more severe disease phenotype than missense mutations or in-frame deletions, as well as small deletions and insertions in the MYBPC3 gene.
Journal ArticleDOI
Effect of the angiotensin II type 2-receptor gene (+1675 G/A) on left ventricular structure in humans.
Roland E. Schmieder,Jeanette Erdmann,Christian Delles,Johannes Jacobi,Eckart Fleck,Karl F. Hilgers,Vera Regitz-Zagrosek +6 more
TL;DR: The data indicate that the X-chromosomal located +1675 G/A-polymorphism of the AT2-R gene is associated with LV structure in young male humans with early structural changes of the heart due to arterial hypertension.