The coordination chemistry of pyridyl oximes

Stereochemical studies. xxxiv. * quantitative description of ring puckering via torsional angles. the case of six-membered rings

It has been long known that certain transition metal sulfides dissolve in aqueous ammonium polysulfide. Although it was assumed that they thereby formed metal polysulfides, attention was first paid to such compounds only a few years ago. In recent years a host of new complexes with polysulfido chelate ligands have been isolated and characterized. The complexes are of interest not only regarding their structure and reactivity but also in view of their potential uses; they can be used for the directed preparation of sulfur rings of a given size, and there are indications that they will find applications in catalysis.

Transition Metal Polysulfides: Coordination Compounds with Purely Inorganic Chelate Ligands

Cytotoxic chelators and chelates 1. Inhibition of DNA synthesis in cultured rodent and human cells by aroylhydrazones and by a copper(II) complex of salicylaldehyde benzoyl hydrazone

Through systematic structure−activity studies of the 2-benzoylpyridine thiosemicarbazone (HBpT), 2-(3-nitrobenzoyl)pyridine thiosemicarbazone (HNBpT) and dipyridylketone thiosemicarbazone (HDpT) series of iron (Fe) chelators, we identified structural features necessary to form Fe complexes with potent anticancer activity (J. Med. Chem. 2007, 50, 3716−3729). In this investigation, we generated the related 2-acetylpyridine thiosemicarbazone (HApT) analogues to examine the influence of the methyl group at the imine carbon. Four of the six HApT chelators had potent antitumor activity (IC50: 0.001−0.002 μM) and Fe chelation efficacy that was similar to the most effective HBpT and HDpT ligands. The HApT Fe complexes had the lowest FeIII/II redox potentials of any thiosemicarbazone series we have generated. This property, in combination with their ability to effectively chelate cellular Fe, make the HApT series one of the most potent antiproliferative agents developed by our group.

2-Acetylpyridine Thiosemicarbazones are Potent Iron Chelators and Antiproliferative Agents: Redox Activity, Iron Complexation and Characterization of their Antitumor Activity

Organometallic sulfur complexes. 1. Syntheses, structures, and characterizations of organoiron sulfane complexes (.mu.-Sx)[(.eta.5-C5H5)Fe(CO)2]2 (x = 1-4)

Syntheses of iron(III) aroyl hydrazones containing pyridoxal and salicylaldehyde. The crystal and molecular structure of two iron(III)-pyridoxal isonicotinoyl hydrazone complexes

Structural studies of Fe(III) and Cu(II) complexes of salycylaldehyde benzoyl hydrazone, a synthetic chelating agent exhibiting diverse biological properties

Structural studies of iron(iii) complexes of the new iron-binding drug, pyridoxal isonicotinoyl hydrazone

http://journals.iucr.org/c/issues/1984/07/00/a23725/a23725.pdf

Structures of cis-dichloro(methanol)(salicylaldehyde benzoylhydrazonato)iron(III), [FeCl2(C14H11N2O2)(CH4O)], and chloro(salicylaldehyde benzoylhydrazonato)copper(II) monohydrate, [CuCl(C14H11N2O2)].H2O

Verner Schomaker

Papers

Organometallic sulfur complexes. 1. Syntheses, structures, and characterizations of organoiron sulfane complexes (.mu.-Sx)[(.eta.5-C5H5)Fe(CO)2]2 (x = 1-4)

Syntheses of iron(III) aroyl hydrazones containing pyridoxal and salicylaldehyde. The crystal and molecular structure of two iron(III)-pyridoxal isonicotinoyl hydrazone complexes

Structural studies of Fe(III) and Cu(II) complexes of salycylaldehyde benzoyl hydrazone, a synthetic chelating agent exhibiting diverse biological properties

Structural studies of iron(iii) complexes of the new iron-binding drug, pyridoxal isonicotinoyl hydrazone

Structures of cis-dichloro(methanol)(salicylaldehyde benzoylhydrazonato)iron(III), [FeCl2(C14H11N2O2)(CH4O)], and chloro(salicylaldehyde benzoylhydrazonato)copper(II) monohydrate, [CuCl(C14H11N2O2)].H2O