V
Veronica Sanna
Researcher at University of Naples Federico II
Publications - 13
Citations - 3263
Veronica Sanna is an academic researcher from University of Naples Federico II. The author has contributed to research in topics: Leptin & Immune system. The author has an hindex of 12, co-authored 13 publications receiving 3148 citations. Previous affiliations of Veronica Sanna include National Research Council.
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Journal ArticleDOI
Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency
I. Sadaf Farooqi,Giuseppe Matarese,Graham M. Lord,Keogh Jm,Elizabeth Lawrence,Chizo Agwu,Veronica Sanna,Susan A. Jebb,Francesco Perna,Silvia Fontana,Robert I. Lechler,Alex M. DePaoli,Stephen O'Rahilly +12 more
TL;DR: The wide range of phenotypic abnormalities seen in the leptin-deficient ob/ob mouse and their reversibility by leptin administration provide compelling evidence for the existence of multiple physiological functions of this hormone in rodents.
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Requirement for Leptin in the Induction and Progression of Autoimmune Encephalomyelitis
Giuseppe Matarese,Antonio Di Giacomo,Veronica Sanna,Graham M. Lord,Jane K. Howard,Antonino Di Tuoro,Stephen R. Bloom,Robert I. Lechler,Serafino Zappacosta,Silvia Fontana +9 more
TL;DR: It is suggested that leptin is required for the induction and maintenance of an effective proinflammatory immune response in the CNS and may provide a key link between nutritional deficiency and immune dysfunction.
Journal ArticleDOI
Leptin surge precedes onset of autoimmune encephalomyelitis and correlates with development of pathogenic T cell responses
Veronica Sanna,Antonio Di Giacomo,Antonio La Cava,Robert I. Lechler,Silvia Fontana,Serafino Zappacosta,Giuseppe Matarese +6 more
TL;DR: Given that leptin appears to regulate EAE susceptibility, inflammatory anorexia, and pathogenic T-cell immune function, it is postulate that it may offer a potential target in the treatment of multiple sclerosis.
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Leptin increase in multiple sclerosis associates with reduced number of CD4+CD25+ regulatory T cells
Giuseppe Matarese,Pietro Biagio Carrieri,Antonio La Cava,Francesco Perna,Veronica Sanna,Veronica De Rosa,Daniela Aufiero,Silvia Fontana,Serafino Zappacosta +8 more
TL;DR: Findings show an inverse relationship between leptin secretion and the frequency of T(Regs) in RRMS and may have implications for the pathogenesis of and therapy for multiple sclerosis.
Journal ArticleDOI
Balancing susceptibility to infection and autoimmunity: a role for leptin?
Giuseppe Matarese,Antonio La Cava,Veronica Sanna,Graham M. Lord,Robert I. Lechler,Silvia Fontana,Serafino Zappacosta +6 more
TL;DR: It is suggested that in less-developed societies, an epidemiological association between susceptibility to infection and malnutrition has been observed, whereas in affluent countries, an increased incidence of autoimmune diseases has been described, and this can be explained partly by taking into consideration the immune effects of the adipocyte-derived hormone leptin.