V
Victor J. Dzau
Researcher at New York Academy of Medicine
Publications - 713
Citations - 68972
Victor J. Dzau is an academic researcher from New York Academy of Medicine. The author has contributed to research in topics: Renin–angiotensin system & Angiotensin II. The author has an hindex of 130, co-authored 688 publications receiving 66047 citations. Previous affiliations of Victor J. Dzau include Roswell Park Cancer Institute & American Heart Association.
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Journal ArticleDOI
Paracrine Mechanisms in Adult Stem Cell Signaling and Therapy
TL;DR: The potential paracrine mechanisms involved in adult stem cell signaling and therapy are reviewed: cytokines and growth factors can induce cytoprotection and neovascularization, and cardiac remodeling, contractility, and metabolism may also be influenced in aParacrine fashion.
Journal ArticleDOI
The Emerging Concept of Vascular Remodeling
Gary H. Gibbons,Victor J. Dzau +1 more
TL;DR: Vascular remodeling is an active process of structural alteration that involves changes in at least four cellular processes -- cell growth, cell death, cell migration, and production or degradation of extracellular matrix -- and is dependent on a dynamic interaction between locally.
Journal ArticleDOI
Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts
Abeel A. Mangi,Nicolas Noiseux,Deling Kong,Huamei He,Mojgan Rezvani,Joanne S. Ingwall,Victor J. Dzau +6 more
TL;DR: Mesenchymal stem cells genetically enhanced with Akt1 can repair infarcted myocardium, prevent remodeling and nearly normalize cardiac performance.
Journal ArticleDOI
Paracrine action accounts for marked protection of ischemic heart by Akt-modified mesenchymal stem cells
Massimiliano Gnecchi,Massimiliano Gnecchi,Huamei He,Olin D. Liang,Luis G. Melo,Luis G. Melo,Luis G. Melo,Fulvio Morello,Fulvio Morello,Hui Mu,Hui Mu,Nicolas Noiseux,Lunan Zhang,Lunan Zhang,Richard E. Pratt,Richard E. Pratt,Joanne S. Ingwall,Victor J. Dzau,Victor J. Dzau +18 more
TL;DR: Paracrine action accounts for marked protection of ischemic heart by Akt-modified mesenchymal stem cells as discussed by the authors, which was shown to be beneficial for the preservation of the heart.
Paracrine action accounts for marked protection of ischemic heart by Akt modified mesenchymal stem cells.
Massimiliano Gnecchi,Huamei He,Nicolas Noiseux,Od Liang,Lunan Zhang,G Melo,Re Pratt,Js Ingwall,Victor J. Dzau +8 more
TL;DR: Paracrine action accounts for marked protection of ischemic heart by Akt-modified mesenchymal stem cells as well as other mechanisms including “self-consistency” and “cell reprograming”.