J
Joanne S. Ingwall
Researcher at Brigham and Women's Hospital
Publications - 220
Citations - 18667
Joanne S. Ingwall is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Creatine kinase & Creatine. The author has an hindex of 63, co-authored 220 publications receiving 17899 citations. Previous affiliations of Joanne S. Ingwall include Howard Hughes Medical Institute & University of California, Los Angeles.
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Journal ArticleDOI
Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts
Abeel A. Mangi,Nicolas Noiseux,Deling Kong,Huamei He,Mojgan Rezvani,Joanne S. Ingwall,Victor J. Dzau +6 more
TL;DR: Mesenchymal stem cells genetically enhanced with Akt1 can repair infarcted myocardium, prevent remodeling and nearly normalize cardiac performance.
Journal ArticleDOI
Paracrine action accounts for marked protection of ischemic heart by Akt-modified mesenchymal stem cells
Massimiliano Gnecchi,Massimiliano Gnecchi,Huamei He,Olin D. Liang,Luis G. Melo,Luis G. Melo,Luis G. Melo,Fulvio Morello,Fulvio Morello,Hui Mu,Hui Mu,Nicolas Noiseux,Lunan Zhang,Lunan Zhang,Richard E. Pratt,Richard E. Pratt,Joanne S. Ingwall,Victor J. Dzau,Victor J. Dzau +18 more
TL;DR: Paracrine action accounts for marked protection of ischemic heart by Akt-modified mesenchymal stem cells as discussed by the authors, which was shown to be beneficial for the preservation of the heart.
Journal ArticleDOI
Evidence supporting paracrine hypothesis for Akt-modified mesenchymal stem cell-mediated cardiac protection and functional improvement
Massimiliano Gnecchi,Huamei He,Nicolas Noiseux,Olin D. Liang,Lunan Zhang,Lunan Zhang,Fulvio Morello,Fulvio Morello,Hui Mu,Hui Mu,Luis G. Melo,Luis G. Melo,Luis G. Melo,Richard E. Pratt,Richard E. Pratt,Richard E. Pratt,Joanne S. Ingwall,Victor J. Dzau,Victor J. Dzau +18 more
TL;DR: The current study demonstrates that conditioned medium from hypoxic Akt‐MSCs markedly inhibits hypoxia‐induced apoptosis and triggers vigorous spontaneous contraction of adult rat cardiomyocytes in vitro, and evidence supporting paracrine hypothesis forAkt‐modified mesenchymal stem cell‐mediated cardiac protection and functional improvement is demonstrated.
Journal ArticleDOI
Myocardial Phosphocreatine-to-ATP Ratio Is a Predictor of Mortality in Patients With Dilated Cardiomyopathy
Stefan Neubauer,Michael Horn,Monika Cramer,Kerstin Harre,John B. Newell,Werner Peters,Thomas Pabst,Georg Ertl,Dietbert Hahn,Joanne S. Ingwall,Kurt Kochsiek +10 more
TL;DR: The myocardial phosphocreatine-to-ATP ratio, measured noninvasively with 31P-MR spectroscopy, is a predictor of both total and cardiovascular mortality in patients with dilated cardiomyopathy.
Journal ArticleDOI
Transcriptional coactivator PGC-1α controls the energy state and contractile function of cardiac muscle
Zoltan Arany,Huamei He,Jiandie D. Lin,Kirsten Hoyer,Christoph Handschin,Okan Toka,Ferhaan Ahmad,Takashi Matsui,Sherry Chin,Pei Hsuan Wu,Igor I. Rybkin,John M. Shelton,Monia Manieri,Saverio Cinti,Frederick J. Schoen,Rhonda S Bassel-Duby,Anthony Rosenzweig,Joanne S. Ingwall,Bruce M. Spiegelman +18 more
TL;DR: Using genetic knockout mice, it is shown that, while PGC-1alpha KO mice appear to retain normal mitochondrial volume in both muscle beds, expression of genes of oxidative phosphorylation is markedly blunted, indicating that P GC-1 alpha is vital for the heart to meet increased demands for ATP and work in response to physiological stimuli.