V
Vikram N. Vakharia
Researcher at University of Maryland, Baltimore County
Publications - 141
Citations - 6028
Vikram N. Vakharia is an academic researcher from University of Maryland, Baltimore County. The author has contributed to research in topics: Virus & Infectious bursal disease. The author has an hindex of 41, co-authored 136 publications receiving 5586 citations. Previous affiliations of Vikram N. Vakharia include National University of San Marcos & Virginia–Maryland Regional College of Veterinary Medicine.
Papers
More filters
Journal ArticleDOI
The Toll pathway is important for an antiviral response in Drosophila
TL;DR: An in vivo Drosophila X virus (DXV)-based screening system is developed that identifies altered sensitivity to viral infection by using DXV's anoxia-induced death pathology and shows that the Toll pathway is required for efficient inhibition of DXV replication in Dosophila.
Journal ArticleDOI
RNAi is an antiviral immune response against a dsRNA virus in Drosophila melanogaster.
TL;DR: Drosophila is established as an ideal model for the study of antiviral RNAi responses in animals and multiple core RNAi pathway genes are identified, including piwi, vasa intronic gene (vig), aubergine (aub), armitage (armi), Rm62, r2d2 and Argonaute2 (AGO2) as having vital roles in this response in whole organisms.
Journal ArticleDOI
Leader protein of foot-and-mouth disease virus is required for cleavage of the p220 component of the cap-binding protein complex.
TL;DR: In this paper, the leader protein of the cap-binding protein complex was found to be required to initiate the cleavage of the p220 protein, which is the first report of a function for leader protein other than that of autocatalytic cleavage.
Journal ArticleDOI
Molecular determinants of virulence, cell tropism, and pathogenic phenotype of infectious bursal disease virus.
Meggin Brandt,Kun Yao,Meihong Liu,Meihong Liu,Robert A. Heckert,Vikram N. Vakharia,Vikram N. Vakharia +6 more
TL;DR: Results show that the virulence and pathogenic-phenotype markers of IBDV reside in VP2, one of the chimeric viruses containing VP2 sequences of the virulent strain, suggesting that VP2 contains the determinants for cell tropism.
Journal ArticleDOI
Molecular basis of antigenic variation in infectious bursal disease virus
TL;DR: Four antigenically different strains of infectious bursal disease virus (IBDV), characterized by their reactivities with a panel of neutralizing monoclonal antibodies, were selected and the putative amino acids involved in the formation of virus-neutralizing epitopes were identified.