Vincent Brondani

TL;DR: The purification and properties of a recombinant human Dicer are described and it is suggested that if ATP participates in the Dicer reaction in mammalian cells, it might be involved in product release needed for the multiple turnover of the enzyme.

TL;DR: The RNAi response can be induced effectively by long dsRNA in nondifferentiated mouse cells grown in culture, and siRNAs recently have been shown to act as potent inducers of RNAi in cultured mammalian cells.

TL;DR: The close relation between structural features of the interaction between TAR and a new type of inhibitory agent, "In-PRiNts" (for inhibitor of protein-ribonucleotide sequences), such as CGP 40336A and those of the Tat-TAR complex was confirmed by RNase A footprinting and by two-dimensional NMR.

TL;DR: Novel highly potent CXCR4 inhibitors with good pharmacokinetic properties were designed and optimized starting from the naturally occurring beta-hairpin peptide polyphemusin II, which has the potential to become a therapeutic compound for application in the treatment of HIV infections, cancer, angiogenesis suppression and inhibition of metastasis, inflammation, and in stem cell transplant therapy.

TL;DR: Upon lentiviral vector-mediated transduction, prolonged antisense effects were obtained for both types of antisense RNAs in the human T-cell line CEM-SS, and combining the two approaches may result in a synergistic effect.