Showing papers by "Vincent Meininger published in 1988"
TL;DR: Results suggest that microtubule proteins are modified in ALS before ultrastructural axonal degeneration, but the significance of these abnormalities remains hypothetical.
Abstract: Fast axonal transport is altered in nerves from amyotrophic lateral sclerosis (ALS) patients. Microtubules are involved in axonal transport. We analyzed the possibility of an involvement of microtubule modifications underlying the alterations in transport using biochemical and morphologic analysis of intercostal nerves from ALS and control patients. In intercostal nerves displaying no morphologic signs of acute neuronal degeneration, two-dimensional gels showed modifications of the group of β tubulins and abnormal spots of proteins, some appearing to be closely related to tau proteins. These results suggest that microtubule proteins are modified in ALS before ultrastructural axonal degeneration, but the significance of these abnormalities remains hypothetical.
20 citations
TL;DR: The results suggest that the cold stability of microtubules is based on biochemical properties of tubulin, and confirm the domain specificity of the heterogeneity oftubulin.
18 citations
TL;DR: Tectal plates of mouse embryos were used to analyze the heterogeneity of tubulin with high resolution isoelectric focusing, at time of appearance of the young neurons and axons, and the increase of the prominence of the alpha-group with regard to the beta-group in the cold-stable pool of tubulins raises the question as to the exact role of Tubulin in thecold stability.
5 citations
TL;DR: The spatial organization of microtubules in mitotic as well as in interphase cells and in axons has been investigated in situ in the embryonic nervous system of mice using high molecular weight polyethylene glycol‐embedded semithin sections and immunofluorescence with a tubulin‐specific polyclonal antibody.
5 citations