Vincenzo Fodale

TL;DR: EPO, administered in its recombinant form, affords significant neuroprotection in experimental TBI model and may hold promise for future clinical applications.

TL;DR: The available data appear to indicate that anaesthetic drugs such as barbiturates, propofol, xenon and most volatile anaesthetics show neuroprotective effects that protect cerebral tissue from adverse events — such as apoptosis, degeneration, inflammation and energy failure — caused by chronic neurodegenerative diseases, ischaemia, stroke or nervous system trauma.

TL;DR: It is argued that administering certain general anaesthetics to elderly patients may worsen amyloid β peptide oligomerisation and deposition and thus increase the risk of developing postoperative cognitive dysfunction.

TL;DR: Propofol-remifentanil anaesthesia induced a dose-dependent low-flow state with preserved cerebral autoregulation, whereas sevoflurane at high doses provided a certain degree of luxury perfusion.

TL;DR: It seems possible to hypothesize that the inhibition of muscarinic cholinergic receptors could have a pivotal role in the pathogenesis not only of post-operative delirium but also the more complex phenomena ofPost-operative cognitive dysfunction.