V
Virginia C. Dunkel
Researcher at National Institutes of Health
Publications - 10
Citations - 498
Virginia C. Dunkel is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Cell culture & Carcinogen. The author has an hindex of 8, co-authored 10 publications receiving 486 citations.
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Journal ArticleDOI
Reproducibility of microbial mutagenicity assays: II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escherichia coli.
Virginia C. Dunkel,Errol Zeiger,David Brusick,Elena C. McCoy,Douglas McGregor,Kristien Mortelmans,Herbert S. Rosenkranz,Vincent F. Simmon +7 more
TL;DR: The intra- and interlaboratory reproducibility of the Salmonella assay with regard to the overall judgment of mutagenic or nonmutagenic was good, but the results in the E coli strain exhibited a high degree of variability between laboratories.
Journal ArticleDOI
Reproducibility of microbial mutagenicity assays: I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol
Virginia C. Dunkel,Errol Zeiger,David Brusick,Elena C. McCoy,Douglas B. McGregor,Kristien Mortelmans,Herbert S. Rosenkranz,Vincent F. Simmon +7 more
TL;DR: The authors decided to compare the animal species and strains used by the National Cancer Institute/National Toxicology Program (NCI/NTP) for animal carcinogenicity studies.
Journal ArticleDOI
Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: methods used and chemicals evaluated.
TL;DR: A general protocol, modified from the one described by Clive and Spector, was followed by two laboratories to evaluate 63 coded chemicals from 16 chemical classes for mutagenic activity at the thymidine kinase locus in L5178Y TK+/- 3.7.2C mouse lymphoma cells.
Journal ArticleDOI
Mutagenic activity of some coffee flavor ingredients.
TL;DR: The mutagenicity of 4 coffee flavor ingredients (chlorogenic acid, caffeic acid, pyrazine, and trigonelline) was evaluated in the Salmonella plate incorporation assay and mouse lymphoma L5178Y TK +/- assay.
Journal ArticleDOI
Collaborative studies on the Salmonella/microsome mutagenicity assay.
TL;DR: A collaborative study was undertaken to determine the interlaboratory reproducibility of this microbial mutagenicity assay and found that two chemicals gave positive results in 2 laboratories; the same 2 chemicals were negative when tested in the third laboratory.