Douglas McGregor

TL;DR: Eighteen chemicals were tested for their mutagenic potential in the L5178Y tk+/− mouse lymphoma cell forward mutation assay by the use of procedures based upon those described by Clive and Spector and Clive et al.

TL;DR: The IPCS human relevance framework for cancer provides an analytical tool to enable the transparent evaluation of the data, identification of key data gaps, and structured presentation of information that would be of value in the further risk assessment of the compound, even if relevancy cannot be excluded.

TL;DR: The Comet assay has high sensitivity for carcinogens, but its specificity is uncertain because few non-carcinogens have been tested and limitations as to the conduct of the assay have not been examined in any depth.

TL;DR: The types of materials considered, their wear and degradation, their cancer epidemiology in both humans and other animals, the published experimental carcinogenicity data and selected data on their toxic, including genotoxic, effects are summarised.

TL;DR: The intra- and interlaboratory reproducibility of the Salmonella assay with regard to the overall judgment of mutagenic or nonmutagenic was good, but the results in the E coli strain exhibited a high degree of variability between laboratories.