V
Vitaliy O. Kaminskyy
Researcher at Karolinska Institutet
Publications - 44
Citations - 12453
Vitaliy O. Kaminskyy is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Autophagy & Apoptosis. The author has an hindex of 23, co-authored 39 publications receiving 9993 citations. Previous affiliations of Vitaliy O. Kaminskyy include National Academy of Sciences of Ukraine.
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Proceedings ArticleDOI
Abstract 833: S100A4 interacts with p53 in the nucleus promoting its degradation.
Lukas M. Orre,Elena Panizza,Vitaliy O. Kaminskyy,Torbjörn Gräslund,Boris Zhivotovsky,Janne Lehtiö +5 more
TL;DR: S 100A4 interacts with p53 increasing its degradation, resulting in higher cell viability and lower apoptosis after cisplatin treatment, and a possible correlation in patients between S100A4 overexpression and cisPlatin resistance could be used to drive treatment selection.
Journal ArticleDOI
Nutrient Deprivation Promotes MCL-1 Degradation in an Autophagy-Independent Manner.
Nikolay V. Pervushin,Viacheslav V Senichkin,A A Kapusta,Anna S. Gorbunova,Vitaliy O. Kaminskyy,Boris Zhivotovsky,Boris Zhivotovsky,Gelina S. Kopeina +7 more
TL;DR: This study has investigated the contribution of autophagy and proteasomal degradation to the regulation of the level of Mcl-1 protein under nutrient deprivation conditions and found that these circumstances cause a decrease in thelevel of M cl-1 in cancer cells in a macroautophagy-independent manner via proteasome degradation.
Posted ContentDOI
Chaperone-mediated Autophagy Deficiency Reprograms Cancer Metabolism Via TGFβ Signaling to drive Mesenchymal Tumor Growth
Xun Clare Zhou,Yong-Cheng Shi,Vera Shirokova,Elena Kochetkova,Tina Becirovic,Boxi Zhang,Vitaliy O. Kaminskyy,Cecilia Lindskog,Per Hydbring,Simon Ekman,Maria Genander,Erik Norberg,Helin Vakifahmetoglu-Norberg +12 more
TL;DR: This study provides a molecular mechanism on the CMA’s tumor-suppressive function by connecting two important oncogenic pathways, the TGFβ signaling and PPP metabolism, to the loss-of-function LAMP2A in mesenchymal cancer types.
Journal ArticleDOI
Knockout validation of LAMP2A antibodies for immunostaining in human cancer cells.
Xun Clare Zhou,Vera Shirokova,Vitaliy O. Kaminskyy,Elena Kochetkova,Erik Norberg,Maria Genander,Helin Vakifahmetoglu-Norberg +6 more
TL;DR: In this article , the authors assessed the specificity of select commercial LAMP2A antibodies on wild-type and LAMP 2A KO human cancer cells, and found that all tested antibodies were suitable for immunoblotting, but the anti-LAMP 2α antibody (ab18528) is likely to exhibit an off-target reactivity in immunostaining approaches.