Cytoscape is an open source software project for integrating biomolecular interaction networks with high-throughput expression data and other molecular states into a unified conceptual framework. Although applicable to any system of molecular components and interactions, Cytoscape is most powerful when used in conjunction with large databases of protein-protein, protein-DNA, and genetic interactions that are increasingly available for humans and model organisms. Cytoscape's software Core provides basic functionality to layout and query the network; to visually integrate the network with expression profiles, phenotypes, and other molecular states; and to link the network to databases of functional annotations. The Core is extensible through a straightforward plug-in architecture, allowing rapid development of additional computational analyses and features. Several case studies of Cytoscape plug-ins are surveyed, including a search for interaction pathways correlating with changes in gene expression, a study of protein complexes involved in cellular recovery to DNA damage, inference of a combined physical/functional interaction network for Halobacterium, and an interface to detailed stochastic/kinetic gene regulatory models.

/pdf/cytoscape-a-software-environment-for-integrated-models-of-2fp1mf0u7b.pdf

Cytoscape: A Software Environment for Integrated Models of Biomolecular Interaction Networks

Inspired by empirical studies of networked systems such as the Internet, social networks, and biological networks, researchers have in recent years developed a variety of techniques and models to help us understand or predict the behavior of these systems. Here we review developments in this field, including such concepts as the small-world effect, degree distributions, clustering, network correlations, random graph models, models of network growth and preferential attachment, and dynamical processes taking place on networks.

/pdf/the-structure-and-function-of-complex-networks-34deompc9l.pdf

The Structure and Function of Complex Networks

http://brainimaging.waisman.wisc.edu/~chung/neuro.processing/literature/rubinov.2010.NI.network.pdf

Complex network measures of brain connectivity: uses and interpretations.

The modern science of networks has brought significant advances to our understanding of complex systems. One of the most relevant features of graphs representing real systems is community structure, or clustering, i. e. the organization of vertices in clusters, with many edges joining vertices of the same cluster and comparatively few edges joining vertices of different clusters. Such clusters, or communities, can be considered as fairly independent compartments of a graph, playing a similar role like, e. g., the tissues or the organs in the human body. Detecting communities is of great importance in sociology, biology and computer science, disciplines where systems are often represented as graphs. This problem is very hard and not yet satisfactorily solved, despite the huge effort of a large interdisciplinary community of scientists working on it over the past few years. We will attempt a thorough exposition of the topic, from the definition of the main elements of the problem, to the presentation of most methods developed, with a special focus on techniques designed by statistical physicists, from the discussion of crucial issues like the significance of clustering and how methods should be tested and compared against each other, to the description of applications to real networks.

/pdf/community-detection-in-graphs-34rogm3r6p.pdf

Community detection in graphs

There is no other package around that satisfies all the following requirements: •Ability to handle large graphs efficiently •Embeddable into higher level environments (like R [6] or Python [7]) •Ability to be used for quick prototyping of new algorithms (impossible with “click & play” interfaces) •Platform-independent and open source igraph aims to satisfy all these requirements while possibly remaining easy to use in interactive mode as well.

The igraph software package for complex network research

This is an extensively revised and expanded second edition of the successful textbook on social network analysis integrating theory, applications, and network analysis using Pajek. The main structural concepts and their applications in social research are introduced with exercises. Pajek software and data sets are available so readers can learn network analysis through application and case studies. Readers will have the knowledge, skill, and tools to apply social network analysis across the social sciences, from anthropology and sociology to business administration and history. This second edition has a new chapter on random network models, for example, scale-free and small-world networks and Monte Carlo simulation; discussion of multiple relations, islands, and matrix multiplication; new structural indices such as eigenvector centrality, degree distribution, and clustering coefficients; new visualization options that include circular layout for partitions and drawing a network geographically as a 3D surface; and using Unicode labels. This new edition also includes instructions on exporting data from Pajek to R software. It offers updated descriptions and screen shots for working with Pajek (version 2.03).

Exploratory Social Network Analysis with Pajek

Large networks, having thousands of vertices and lines, can be found in many different areas, e. g: genealogies, flo w graphs of programs, molecule, computer networks, transportation networks, social networks, intra/inter organisational networks ... Many standard network algorithms are very time and space consuming and therefore unsuitable for analysis of such networks. In the article we present some approaches to analysis and visualisation of large networks implemented in programPajek. Some typical examples are also given.

/pdf/pajek-program-for-large-network-analysis-30f6eh12a9.pdf

Pajek - Program for Large Network Analysis

In the paper an introduction to main social networks centrality measures is given. A new view on these measures is proposed, based on relational algebra . All described measures are implemented in computer programs CENTRAL and FLOWIND.

/pdf/centrality-in-social-networks-hshnm85j9k.pdf

Centrality in Social Networks

Pajek (spider, in Slovene) is a program package, for Windows (32 bit), for analysis and visualization of large networks (having thousands of vertices). It is freely available, for noncommercial use, at its home page: http://vlado.fmf.uni-lj.si/pub/networks/pajek/

/pdf/pajek-analysis-and-visualization-of-large-networks-3jaq3uxw2b.pdf

Pajek - Analysis and Visualization of Large Networks

The structure of large networks can be revealed by partitioning them to smaller parts, which are easier to handle. One of such decompositions is based on $k$--cores, proposed in 1983 by Seidman. In the paper an efficient, $O(m)$, $m$ is the number of lines, algorithm for determining the cores decomposition of a given network is presented.

Vladimir Batagelj

Papers

Exploratory Social Network Analysis with Pajek

Pajek - Program for Large Network Analysis

Centrality in Social Networks

Pajek - Analysis and Visualization of Large Networks

An O(m) Algorithm for Cores Decomposition of Networks