V
Vladimir R. Muzykantov
Researcher at University of Pennsylvania
Publications - 330
Citations - 17641
Vladimir R. Muzykantov is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Endothelium & Nanocarriers. The author has an hindex of 66, co-authored 318 publications receiving 15229 citations. Previous affiliations of Vladimir R. Muzykantov include Hebrew University of Jerusalem & Oklahoma Medical Research Foundation.
Papers
More filters
Journal ArticleDOI
Multifunctional Nanoparticles: Cost Versus Benefit of Adding Targeting and Imaging Capabilities
TL;DR: The trade-off between additional functionality and complexity is the subject of ongoing debate and the focus of this Review.
Journal ArticleDOI
Control of endothelial targeting and intracellular delivery of therapeutic enzymes by modulating the size and shape of ICAM-1-targeted carriers.
Silvia Muro,Carmen Garnacho,Julie A. Champion,John Leferovich,Christine Gajewski,Edward H. Schuchman,Samir Mitragotri,Vladimir R. Muzykantov +7 more
TL;DR: Carrier geometry was found to influence endothelial targeting in the vasculature, and the rate of endocytosis and lysosomal transport within ECs, and rational design of carrier geometry will help optimize endothelium-targeted therapeutics.
Journal ArticleDOI
Targeting vascular (endothelial) dysfunction
Andreas Daiber,Sebastian Steven,Alina Weber,Vladimir V. Shuvaev,Vladimir R. Muzykantov,Ismail Laher,Huige Li,Santiago Lamas,Thomas Münzel +8 more
TL;DR: Assessing vascular function, including that of smooth muscle and even perivascular adipose tissue, may be an appropriate parameter for clinical investigations, and alternative diagnostic parameters such as vascular stiffness index and intima/media thickness ratio are discussed.
Journal ArticleDOI
Drug delivery by red blood cells: vascular carriers designed by mother nature
TL;DR: New approaches for encapsulating drugs into RBC and coupling to RBC surface provide promising avenues for safe and widely useful improvement of drug delivery in the vascular system.
Journal ArticleDOI
A novel endocytic pathway induced by clustering endothelial ICAM-1 or PECAM-1
Silvia Muro,Rainer Wiewrodt,Anu P. Thomas,Lauren Koniaris,Steven M. Albelda,Vladimir R. Muzykantov,Michael Koval +6 more
TL;DR: Interestingly, these kinases are part of the signal transduction pathways that are activated when circulating leukocytes engage endothelial cell adhesion molecules, suggesting the possibility that CAM-mediated endocytosis is regulated using comparable signaling pathways.