V
Vyom Shukla
Researcher at Scripps Research Institute
Publications - 4
Citations - 105
Vyom Shukla is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: Alkylation & Structure–activity relationship. The author has an hindex of 3, co-authored 4 publications receiving 64 citations.
Papers
More filters
Journal ArticleDOI
Inverse Electron Demand Diels-Alder Reactions of Heterocyclic Azadienes, 1-Aza-1,3-Butadienes, Cyclopropenone Ketals, and Related Systems. A Retrospective.
TL;DR: A summary of the investigation and applications of the inverse electron demand Diels-Alder reaction is provided that have been conducted in the laboratory over a period of more than 35 years, which continues to provide solutions to complex synthetic challenges.
Journal ArticleDOI
Divergent Total Syntheses of (-)-Pseudocopsinine and (-)-Minovincinine.
TL;DR: The first total syntheses of (-)-pseudocopsinine and (-)-minovincine from a common intermediate 8 are detailed, enlisting late-stage, hydrogen atom transfer (HAT)-mediated free radical bond formations (C20-C2 and C20-OH, respectively) that are unique to their core or structure.
Journal ArticleDOI
Vinblastine 20′ Amides: Synthetic Analogues That Maintain or Improve Potency and Simultaneously Overcome Pgp-Derived Efflux and Resistance
John C. Lukesh,Daniel W. Carney,Huijun Dong,R. Matthew Cross,Vyom Shukla,Katharine K. Duncan,Shouliang Yang,Daniel M. Brody,Manuela M. Brütsch,Aleksandar Radakovic,Dale L. Boger +10 more
TL;DR: The improvements in potency directly correlated with target tubulin binding affinity, and the reduction in differential functional activity against the sensitive and Pgp overexpressing resistant cell lines was found to correlate directly with an impact on Pgp-derived efflux.
Journal ArticleDOI
Synthesis and evaluation of duocarmycin SA analogs incorporating the methyl 1,2,8,8a-tetrahydrocyclopropa[c]imidazolo[4,5-e]indol-4-one-6-carboxylate (CImI) alkylation subunit.
TL;DR: The design, synthesis, and evaluation of methyl 1,2,8,8a-tetrahydrocyclopropa[c]imidazolo[4,5-e]indol-4-one-6-carboxylate derivatives are detailed representing analogs of duocarmycin SA and yatakemycin containing an imidazole replacement for the fused pyrrole found in the DNA alkylation subunit.