Showing papers in "Bioorganic & Medicinal Chemistry in 2016"

TL;DR: The main focus of the present review is to provide an ample but condensed overview on various synthetic approaches providing access to quinazoline andQuinazolinone compounds with multifaceted biological activities.

TL;DR: Novel methods of total synthesis, including a recent one that is carried out entirely on a solid phase, will enable a more thorough and systematic exploration of the sequence space of daptomycin.

TL;DR: This review selected 18 representative known agrochemicals containing a pyridine moiety and extrapolate their discovery from the perspective of Intermediate Derivatization Methods in the hope that this approach will have greater appeal to researchers engaged in the discovery of agrochemical and/or pharmaceuticals.

TL;DR: In the present study a series of urea and sulfamide compounds incorporating the tetralin scaffolds were synthesized and evaluated for their acetylcholinesterase (AChE), human carbonic anhydrase (CA, EC 4.2.1) isoenzyme I, and II (hCA I and hCA II) inhibitory properties.

TL;DR: The additive CHARMM General Force Field is extended to include halogen-virtual particle interactions in model systems of phenyl-X, with X being Cl, Br or I including di- and trihalogenated species, to improve the representation of halogen bonding.

TL;DR: A Gestalt approach to understanding the chemical requirements for GN entry seems a useful adjunct that might consist of characterizing compounds which reach the cytoplasm, grouping (or binning) by routes of entry and formulating chemical 'rules' for those bins.

TL;DR: Oxathiapiprolin is the first member of a new class of piperidinyl thiazole isoxazoline fungicides with exceptional activity against plant diseases caused by oomycete pathogens, resulting in excellent preventative, curative and residual efficacy against key diseases of grapes, potatoes and vegetables.

TL;DR: In this review, the synthesis of 30 agrochemicals that received an international standardization organization (ISO) name during the last five years (January 2010 to December 2014) is described.

TL;DR: The structure activity relationship study that led to the discovery of the 6-aryl-picolinate herbicides Arylex active (2005) and Rinskor™ active (2010) is described.

TL;DR: Although the site of action for des methyl-broflanilide appears to overlap with that of macrocyclic lactones, different modes of actions have been demonstrated for desmethyl- BroflanILide and the macrocyclIC lactones.

TL;DR: The synthesis and antifungal activities of 18 alkylated mono-, bis-, and trisbenzimidazole derivatives, their toxicities against mammalian cells, as well as their ability to induce reactive oxygen species (ROS) in yeast cells are reported.

TL;DR: This annual review covers the synthesis of thirty-seven NCEs that were approved for the first time in 2014 and one drug which was approved in 2013 and was not covered in a previous edition of this review.

TL;DR: Interestingly, 3f, 3g and 3m could inhibit both NA and 3CLpro and serve as a starting point to develop broad-spectrum antiviral agents.

TL;DR: This review summarizes the recent advances in the development of FtsZ inhibitors, focusing on those in the last 5years, but also includes significant findings in previous years.

TL;DR: Omadacycline offers once daily oral and IV dosing and a clinical tolerability and safety profile that compares favorably with contemporary antibiotics used across serious community-acquired infections where resistance has rendered many less effective.

TL;DR: The PK/PD index and target drug exposures obtained in validated animal infection models are critical components in optimizing dosing regimen design in order to maximize efficacy while minimize the cost and duration of clinical trials.

TL;DR: The aim of this review article is to describe the various factors that have contributed to the current state of antimicrobial resistance and to evaluate potential strategies developed to reduce the burden of antimacterial resistance.

TL;DR: Results suggested that chalcone 8o may be of value as both a HIV prophylactic and therapy and O-benzyl-substituted chalcones were identified as promising anti-HIV agents for future investigation.

TL;DR: A new series of compounds, 2-substituted mercapto-3-[2-(pyridin-2-yl)ethyl]-4(3H)-quinazolinone 1-21, was synthesized and evaluated for in vivo anti-inflammatory and analgesic activities and in vitro COX-1/COX-2 inhibition.

TL;DR: 5m was the most potent inhibitor for eeAChE and eqBuChE, and it was also a good and balanced inhibitor to hChEs and hMAO-B, and molecular modeling and kinetic studies revealed that 5m might be a promising multi-target lead candidate worthy of further pursuit.

TL;DR: The doom and gloom of antibiotic resistance dominates public perception of this drug class and the world needs new antibiotic molecules to replace the exhausted pipeline and the second 'golden era' is certain to come from Nature's chemical inventory once again.

TL;DR: Five 1,3,5-trisubstituted pyrazoline derivatives showed more potent anti-inflammatory and analgesic activities than the reference drug celecoxib and were selected to test their inhibitory activities against ovine COX-1/2 using an in vitro cyclooxygenase inhibition assay.

TL;DR: Eight new coumarin substituted silver(I) N-heterocyclic carbene (NHC) complexes were synthesized by the interaction of the corresponding imidazolium or benzimidazlium chlorides and Ag2O in dichloromethane at room temperature and showed good activities against different microorganisms.

TL;DR: A kinetic and X-ray crystallographic study of a congener of SLC-0111 which incorporates a thioureido instead of ureido linker between the two aromatic rings as inhibitor of four physiologically relevant CA isoforms is reported.

TL;DR: The SAR analysis indicated that keeping the free thiosemicarbazide moiety is crucial to obtain this antiviral activity, since the cyclization products (7a–7g) did not produce any antiviral effect.

TL;DR: Best protection was provided by chalcones that combined good inhibitory potency with high radical scavenging ability in a single molecule, an observation that points to a potential therapeutic value of this compound class.

TL;DR: A series of 4-hydroxyl aurone derivatives were designed synthesized and evaluated as potential multifunctional agents for the treatment of Alzheimer's disease and demonstrated that most of the derivatives exhibited good multifunctionsal properties.

TL;DR: The binding determinants of Keap1-Nrf2 proteins are shown and mechanistic insights on Nrf2 activation potential of pterostilbene are provided.

TL;DR: The results indicate that a new series of N,N-disubstituted 2-aminothiazolines could serve as BChE and CaE inhibitors for potential medicinal applications.

TL;DR: This paper describes the synthesis and evaluation of new dihydropyrimidinone (DHPM)-derived selenoesters as potential multi-targeted agents for the treatment of Alzheimer's disease and shows good potential for the development of antioxidant and anticholinesterasic agents.