W A Crowell

TL;DR: Exposure to omega-6 PUFA enhanced renal injury; supplementation with omega-3 PUFA was renoprotective, and the effects of variations in dietary PUFA composition on the chronic course of induced renal disease in dogs were investigated.

TL;DR: Early in renal insufficiency, before significant kidney damage, group FO had a lower serum cholesterol concentration and tended to have a lower urinary prostaglandin E2 and thromboxane A2 excretion than group C, while group SO had a higher mean glomerular capillary pressure and more glomersular enlargement, which could explain the beneficial effects of omega-3 PUFAs and the detrimental effects when administered on a long-term basis.

TL;DR: Dog survival was significantly enhanced by 0.4% P diets (vs 1.4%) and urine protein excretion was not significantly affected by dietary amount of either protein or P, when measured by either timed urine collection or urine protein-to-creatinine ratio.

TL;DR: Data suggest that inhibition of angiotensin converting enzyme was effective in modulating progressive renal injury, which was associated with reduction ofglomerular and systemic hypertension and proteinuria but not glomerular hypertrophy.

TL;DR: Self-perpetuation of renal injury in dogs could be the sole mechanism by which naturally occurring renal diseases progress, and clinical results from creatinine measurements on cases of naturally occurring disease should not be interpreted too stringently.