W
W. Niezgoda
Researcher at University of Michigan
Publications - 3
Citations - 79
W. Niezgoda is an academic researcher from University of Michigan. The author has contributed to research in topics: Mutant & Structural gene. The author has an hindex of 3, co-authored 3 publications receiving 79 citations.
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Journal Article
Genetic analysis of thirty-three platelet polypeptides detected in two-dimensional polyacrylamide gels.
TL;DR: Two-dimensional gel electrophoresis followed by silver-staining was utilized to visualize platelet polypeptides for genetic analysis and the observed index of heterozygosity of 2.55% is comparable to the previously reported findings for red cell proteins.
Journal ArticleDOI
Estimation of mutation rates based on the analysis of polypeptide constituents of cultured human lymphoblastoid cells.
Ernest H. Y. Chu,Michael Boehnke,S. M. Hanash,Rork Kuick,Barbara J. Lamb,James V. Neel,W. Niezgoda,S. Pivirotto,G. Sundling +8 more
TL;DR: An excess of structural gene mutations at ten known polymorphic loci and repeat mutations at these and other loci suggest nonrandomness of mutation in human somatic cells, and nullimorphs occurring at three heterozygous loci in TK-6 cells may be caused by genetic processes other than structural gene mutation.
Journal ArticleDOI
Detection of human somatic cell structural gene mutations by two-dimensional electrophoresis.
S. M. Hanash,Ernest H. Y. Chu,Rork Kuick,Michael M. Skolnick,James V. Neel,John R. Strahler,S. Pivirotto,W. Niezgoda +7 more
TL;DR: The results indicate the usefulness of the two‐dimensional approach for mutagenesis studies at the protein level and show the feasibility of detecting human somatic structural gene mutations by two dimensional electrophoresis.